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CAS RN: 156153-43-4 | Product Number: A5558
DBD-COCl [=4-(N,N-Dimethylaminosulfonyl)-7-(N-chloroformylmethyl-N-methylamino)-2,1,3-benzoxadiazole] [for HPLC Labeling]
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![DBD-COCl [=4-(N,N-Dimethylaminosulfonyl)-7-(N-chloroformylmethyl-N-methylamino)-2,1,3-benzoxadiazole] [for HPLC Labeling]](/_ui/responsive/theme-tci/images/missing_product_zoom.jpg "DBD-COCl [=4-(N,N-Dimethylaminosulfonyl)-7-(N-chloroformylmethyl-N-methylamino)-2,1,3-benzoxadiazole] [for HPLC Labeling]")
Purity: >93.0%(T)
Synonyms:
- 4-(N,N-Dimethylaminosulfonyl)-7-(N-chloroformylmethyl-N-methylamino)benzofurazan
- 4-(N,N-Dimethylaminosulfonyl)-7-(N-chloroformylmethyl-N-methylamino)-2,1,3-benzoxadiazole
Product Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
|---|---|---|---|---|
| 100MG |
182,00 €
|
1 | ≥40 |
|
*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).
| Product Number | A5558 |
| Purity / Analysis Method | >93.0%(T) |
| Molecular Formula / Molecular Weight | C__1__1H__1__3ClN__4O__4S = 332.76 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Frozen (<0°C) |
| Store Under Inert Gas | Store under inert gas |
| Condition to Avoid | Moisture Sensitive,Heat Sensitive |
| Packaging and Container | 100MG-Glass Bottle with Plastic Insert (View image) |
| CAS RN | 156153-43-4 |
| PubChem Substance ID | 87563176 |
| MDL Number | MFCD00191377 |
Specifications
| Appearance | Light yellow to Yellow to Orange powder to crystal |
| Purity(Argentometric Titration) | min. 93.0 % |
| Effect test of HPLC derivatization | Effective as labeling agent for Benzylamine |
Properties (reference)
GHS
| Pictogram |
|
| Signal Word | Danger |
| Hazard Statements | H314 : Causes severe skin burns and eye damage. H290 : May be corrosive to metals. |
| Precautionary Statements | P260 : Do not breathe dust. P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection/ hearing protection. P303 + P361 + P353 : IF ON SKIN (or hair): Take off immediately all contaminated clothing. Rinse skin with water. P301 + P330 + P331 : IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. P304 + P340 + P310 : IF INHALED: Remove person to fresh air and keep comfortable for breathing. Immediately call a POISON CENTER/doctor. P305 + P351 + P338 + P310 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Immediately call a POISON CENTER/doctor. |
Related Laws:
Transport Information:
| UN Number | UN3261 |
| Class | 8 |
| Packing Group | III |
| HS Number | 2935909099 |
Application
HPLC Labeling Reagent
The compound 1 is an HPLC fluorescence labeling reagent, which reacts with many kinds of nucleophilic groups under mild conditions. The reaction examples are shown in the table below.
These resulting compounds are stable, and can reach the detector without any decomposition under reversed phase HPLC, thus excellent chromatograms can be obtained by fluorescence detection.
These resulting compounds are stable, and can reach the detector without any decomposition under reversed phase HPLC, thus excellent chromatograms can be obtained by fluorescence detection.
| Groups | Examples | Reaction Conditions | Wavelengths (nm) | Detection Limits (fmol) | |
|---|---|---|---|---|---|
| ex | em | ||||
| Alcohols | Androsterone | 60℃, 30 min | 443 | 546 | 38 |
| α-Oxyacids | Mandelic acid | 60℃, 15 min | 442 | 551 | 125 |
| Phenols | Estrone | 60℃, 15 min | 440 | 543 | 40 |
| Amines | Benzylamine | r.t. or 60℃, 15 min | 445 | 555 | 89 |
| Aromatic amines | Phenetidine | 60℃, 15 min | 443 | 553 | 56 |
| Thiols | 2-Mercapto-N-(2-naphthyl)acetamide | r.t. | 437 | 544 | 103 |
Application examples:
10 µL of 25 mM labeling reagent 1 in dry benzene is mixed with 10 µL of 0.5 mM androsterone in dry benzene (containing 0.5 mM quinuclidine＊), and incubated at 60 °C for 30 min. The reaction solution is quenched with 980 µL of 50% acetonitrile solution containing 1% acetic acid, use it as the HPLC sample solution.
＊For primary alcohols, quinuclidine is not necessarily needed.
10 µL of 25 mM labeling reagent 1 in dry benzene is mixed with 10 µL of 0.5 mM androsterone in dry benzene (containing 0.5 mM quinuclidine＊), and incubated at 60 °C for 30 min. The reaction solution is quenched with 980 µL of 50% acetonitrile solution containing 1% acetic acid, use it as the HPLC sample solution.
＊For primary alcohols, quinuclidine is not necessarily needed.
TCI Products Pamphlet
HPLC Labeling Reagents ( PDF 10MB )
HPLC Labeling Reagents ( PDF 10MB )
References
- 1)K. Imai, T. Fukushima, H. Yokosu, Biomed. Chromatogr. 1994, 8, 107.
- 2)Tokyo Kasei Kogyo Co. Ltd., Jpn. Kokai Tokkyo Koho 95 238075, 1995.
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