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CAS RN: 111470-99-6 | Product Number: A2353
Amlodipine Besylate
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Purity: >98.0%(HPLC)(N)
Synonyms:
- 3-Ethyl 5-Methyl 2-(2-Aminoethoxy)methyl-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate Benzenesulfonate
- 2-(2-Aminoethoxy)methyl-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylic Acid 3-Ethyl 5-Methyl Ester Benzenesulfonate
Product Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
|---|---|---|---|---|
| 1G |
€49.00
|
1 | ≥40 |
|
| 5G |
€167.00
|
1 | ≥40 |
|
*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).
| Product Number | A2353 |
| Purity / Analysis Method | >98.0%(HPLC)(N) |
| Molecular Formula / Molecular Weight | C__2__0H__2__5ClN__2O__5·C__6H__5SO__3H = 567.05 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Room Temperature (Recommended in a cool and dark place, <15°C) |
| Packaging and Container | 1G-Glass Bottle with Plastic Insert (View image) |
| CAS RN | 111470-99-6 |
| Related CAS RN | 88150-42-9 |
| Reaxys Registry Number | 8378713 |
| PubChem Substance ID | 125307717 |
| SDBS (AIST Spectral DB) | 52867 |
| Merck Index (14) | 491 |
| MDL Number | MFCD00887594 |
Specifications
| Appearance | White to Dark green powder to crystal |
| Purity(HPLC) | min. 98.0 %(total of isomer) |
| Purity(with Total Nitrogen) | min. 98.0 % |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 200 °C(dec.) |
| Solubility in water | Slightly soluble |
GHS
| Pictogram |
|
| Signal Word | Warning |
| Hazard Statements | H302 : Harmful if swallowed. H315 : Causes skin irritation. H319 : Causes serious eye irritation. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P270 : Do not eat, drink or smoke when using this product. P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ eye protection/ face protection. P337 + P313 : If eye irritation persists: Get medical advice/ attention. P301 + P312 + P330 : IF SWALLOWED: Call a POISON CENTER/doctor if you feel unwell. Rinse mouth. |
Related Laws:
| RTECS# | US7967700 |
Transport Information:
| HS Number | 2933399990 |
Application
Amlodipine Besylate: A Long-Acting Dihydropyridine-Type Calcium Channel Antagonist
Amlodipine besylate is a long-acting dihydropyridine-type calcium channel antagonist or blocker (CCB) that causes vasodilatation by blocking the influx of calcium ions through L-type calcium channels in cell membranes. Amlodipine besylate is slightly soluble in water, sparingly soluble in ethanol and soluble in methanol. Recently, some combination agents with an angiotensin II antagonist (ARB), such as irbesartan [I0859] and valsartan [V0112], are used for the treatment of hypertension and cardiovascular disease. For your reference, [P2406] is an impure substance in the synthesis of amlodipine besylate. (The product is for research purpose only.)
References
- Comparison of location and binding for the positively charged 1,4-dihydropyridine calcium channel antagonist amlodipine with uncharged drugs of this class in cardiac membranes.
- Amlodipine. A review of its pharmacodynamic and pharmaockinetic properties, and therapeutic use in cardiovascular disease
- Amlodipine: A reappraisal of its Pharmacological Properties and Therapeutic Use in Cardiovascular Disease
- Inhibition of excessive neuronal apoptosis by the calcium antagonist amlodipine and antioxidants in cerebellar granule cells
- Novel vascular biology of 3rd-generation L-type calcium channel antagonists
- A stability-indicating high performance liquid chromatographic (HPLC) assay for the simultaneous determination of atorvastatin and amlodipine in commercial tablets
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