Caution Notice:
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Maximum quantity allowed is 999
AMP-Activated Protein Kinase (AMPK) Activator
A769662 (1) is a cell-permeable activator of AMP-activated protein kinase (AMPK).1) 1 was found to directly stimulate partially purified rat liver AMPK with EC50 = 0.8 μM and inhibited fatty acid synthesis in primary rat hepatocytes with IC50 = 3.2 μM.1)
1 provided significant stimulation to purified rat liver AMPK (EC50 = 116 nM) and stimulation of the kinase by 1 was 50 times more potent than that by AMP.2) The mechanism of activation of AMPK by 1 is allosteric and involves inhibiting dephosphorylation of the kinase on Thr-172.3) 1 inhibits reprogramming of somatic cells into induced pluripotent stem cells (iPSCs)4) and proliferation of mesenchymal stem cells.5)
References
- 1) Identification and characterization of a small molecule AMPK activator that treats key components of type 2 diabetes and the metabolic syndrome
- 2) Mechanism of Action of A-769662, a Valuable Tool for Activation of AMP-activated Protein Kinase
- 3) Defining the Mechanism of Activation of AMP-activated Protein Kinase by the Small Molecule A-769662, a Member of the Thienopyridone Family
- 4) Mechanism of Action of A-769662, a Valuable Tool for Activation of AMP-activated Protein Kinase
- 5) Role of AMP-activated protein kinase in regulating hypoxic survival and proliferation of mesenchymal stem cells
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