Caution Notice:
It has come to our notice that certain fraudulent individuals or entities are misusing our Company’s name and TCI’s registered trademarks by promoting and offering for sale regulated and hazardous chemical substances, including Potassium Cyanide, through online platforms like YouTube. We hereby categorically clarify that TCI has no association or connection whatsoever with the products being displayed or sold in these or similar videos. These products have been falsely represented as being associated with TCI, and the unauthorized use of our trademark and brand name is both illegal and misleading. TCI Chemicals is a responsible global organization committed to adhering to all applicable international and domestic regulatory frameworks. We do not manufacture, distribute, or engage in the sale of regulated chemical substances in India or in any other jurisdiction unless specifically authorized by the relevant laws and regulatory agencies. All our operations and offerings are governed by stringent safety, quality, and compliance protocols in accordance with applicable laws. Further, TCI Chemicals markets and sells its products exclusively through its official website and authorized distributors. We do not sell, endorse, or supply our products through any third-party platforms, unauthorized agents, or resellers. Any individual or organization purchasing products outside these official channels does so at their own risk, and TCI disclaims all responsibility and liability for any consequences arising therefrom. Members of the public, customers, and partners are strongly advised to exercise caution and conduct due diligence before engaging in any transactions involving products claiming association with TCI Chemicals. The official list of our authorized distributors is publicly available and may be accessed at: https://www.tcichemicals.com/IN/en/distributor/index. We are currently pursuing appropriate legal remedies against those misusing our brand, and we reserve all rights available to us under applicable intellectual property and criminal laws. If you become aware of any such fraudulent activity or require clarification, you may reach out to us at: Sales-IN@TCIchemicals.com. Your vigilance and cooperation are essential in safeguarding the public interest and protecting the integrity of the TCI brand.
Maximum quantity allowed is 999
Histone Methyl Transferase (HMTase) Inhibitor
Histone lysine methylation plays important roles in the organization of chromatin domains and the regulation of gene expression. Among histone lysine methyltransferases (HKMTs) in mammals, G9a and G9a like protein (GLP) are the primary enzymes for mono- and dimethylation at Lys 9 of histone H3 (H3K9me1 and H3K9me2, respectively) and exist for the most part as a G9a–GLP heteromeric complex.1)
BIX 01294 (1) inhibits H3K9 methylation by GLP, G9a HKMTs,2,3) and H3K36 methylation by oncoproteins4) (Table). The inhibition is caused by binding of 1 to the substrate peptide groove of GLP.3) 1 can improve the reprogramming efficiency of mouse embryonic fibroblasts or fetal neural progenitor cells to induced pluripotent stem cells without using c-Myc and SOX2.5,6)
Table. Inhibition of methylation by 1
References
- 1) H3K9 methyltransferase G9a and the related molecule GLP
- 2) Reversal of H3K9me2 by a Small-Molecule Inhibitor for the G9a Histone Methyltransferase
- 3) Structural basis for G9a-like protein lysine methyltransferase inhibition by BIX-01294
- 4) BIX-01294 inhibits oncoproteins NSD1, NSD2, and NSD3
- 5) Induction of Pluripotent Stem Cells from Mouse Embryonic Fibroblasts by Oct4 and Klf4 with Small-Molecule Compounds
- 6) A Combined Chemical and Genetic Approach for the Generation of Induced Pluripotent Stem Cells
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