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Maximum quantity allowed is 999
Recombinant Antiviral Lectin GRFT
- R0229
- Recombinant Griffithsia sp. lectin (= rGRFT) (1)
- R0234
- rGRFT-Biotin [for Manα(1-2)Man] (2)
- R0239
- rGRFT-LecBeads [for Manα(1-2)Man] (3)
The GRFT (1) known as Griffithsin is an α-mannose-binding lectin derived from red algae. Its antiviral activity against various viruses such as HIV, SARS-CoV, HCV, and Ebola virus, has been reported.1,2) The antiviral function of lectins is generally thought to interfere with the entry of virus particles into cells through specific binding to oligosaccharide structures of glycoproteins on the virus surface, and an interaction of GRFT with SARS-CoV-2 has also been suggested.3)
In addition to an Escherichia coli recombinant GRFT, we have a lineup of biotinylated rGRFT-Biotin (2), which is effective for detection and immunoprecipitation, and rGRFT-LecBeads (3), which are immobilized on agarose for capturing glycoproteins such as viruses.
rGRFT were commercialized under license from National Institute of Advanced Industrial Science and Technology (AIST).
rGRFT-LecBeads were developed in collaboration with AIST.
References
- 1) (review) Griffithsin, a Highly Potent Broad-Spectrum Antiviral Lectin from Red Algae: From Discovery to Clinical Application
- 2) Man-Specific Lectins from Plants, Fungi, Algae and Cyanobacteria, as Potential Blockers for SARS-CoV, MERS-CoV and SARS-CoV-2 (COVID-19) Coronaviruses: Biomedical Perspectives
- 3) Sensing the interactions between carbohydrate-binding agents and N-linked glycans of SARS-CoV-2 spike glycoprotein using molecular docking and simulation studies
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