Recombinant Antiviral Lectin GRFT

　The GRFT (1) known as Griffithsin is an α-mannose-binding lectin derived from red algae. Its antiviral activity against various viruses such as HIV, SARS-CoV, HCV, and Ebola virus, has been reported.^1,2) The antiviral function of lectins is generally thought to interfere with the entry of virus particles into cells through specific binding to oligosaccharide structures of glycoproteins on the virus surface, and an interaction of GRFT with SARS-CoV-2 has also been suggested.³⁾
　In addition to an Escherichia coli recombinant GRFT, we have a lineup of biotinylated rGRFT-Biotin (2), which is effective for detection and immunoprecipitation, and rGRFT-LecBeads (3), which are immobilized on agarose for capturing glycoproteins such as viruses.

References

• 1) (review) Griffithsin, a Highly Potent Broad-Spectrum Antiviral Lectin from Red Algae: From Discovery to Clinical Application
• C. Lee, Mar. Drugs 2019, 17, 567.
• 2) Man-Specific Lectins from Plants, Fungi, Algae and Cyanobacteria, as Potential Blockers for SARS-CoV, MERS-CoV and SARS-CoV-2 (COVID-19) Coronaviruses: Biomedical Perspectives
• A. Barre, E. J. M. Van Damme, M. Simplicien, S. Le Poder, B. Klonjkowsk, H. Benoist, D. Peyrade, P. Rougé, Cells 2021, 10, 1619.
• 3) Sensing the interactions between carbohydrate-binding agents and N-linked glycans of SARS-CoV-2 spike glycoprotein using molecular docking and simulation studies
• K. B. Lokhande, G. R. Apte, A. Shrivastava, A. Singh, J. K. Pal, K. V. Swamy, R. K. Gupta, J. Biomol. Struct. Dyn. 2020, 1.

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