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Stearoyl-CoA Desaturase Inhibitor
No.170(July 2016)
Research progresses of iPSCs (induced pluripotent stem cells) and ESCs (embryonic stem cells) are expected that their differentiation into various cell type are applied to regenerative medicine.1-3) However, their properties, self-renewing and differentiation, make these cells tumorigenic.4-7) The tumor formation was found to positively correlate with the residual undifferentiated pluripotent cells.6)
PluriSIn 1 (1) a stearoyl-CoA desaturase inhibitor, resulting in inhibition of oleate synthesis, and can eliminate human pluripotent stem cells (hPSCs) selectively.8) Ben-David et al. have proposed mechanism that the inhibition selectively leads to endoplasmic reticulum (ER) stress, unfolded protein response, and translational attenuation in hPSCs, which finally result in apoptosis.8)
References
- 1)Establishment in culture of pluripotential cells from mouse embryos
- 2)Isolation of a pluripotent cell line from early mouse embryos cultured in medium conditioned by teratocarcinoma stem cells
- 3)Induction of pluripotent stem cells from adult human fibroblasts by defined factors
- 4)Adaptation to culture of human embryonic stem cells and oncogenesis in vivo
- 5)The tumorigenicity of human embryonic and induced pluripotent stem cells
- 6)Variation in the safety of induced pluripotent stem cell lines
- 7) Human induced pluripotent stem cells develop teratoma more efficiently and faster than human embryonic stem cells regardless the site of injection
- 8)Selective elimination of human pluripotent stem cells by an oleate synthesis inhibitor discovered in a high-throughput screen
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