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A New Curcumin Analogue with Enhanced Antitumor Activities
No.168(January 2016)
Curcumin (2) has chemopreventive and chemotherapeutic potentials against various types of cancers, but low bioavailability prevents its use in chemotherapeutic applications. GO-Y030 (1) is a new synthetic analogue of 2, developed by Shibata and Iwabuchi et al. to increase its potential and circumvent its low bioavailability. 1 has been reported that it shows a 30-fold greater suppression of tumor cell growth compared with 2.1) 1 has been reported that it inhibits signal transducers and activators of transcription 3 (STAT3)2a,b) and IKKβ kinase,2c) and suppresses tumor growth of cancer stem cells.2b) Additionally, the structure activity relationships of the antitumor 1 have been reported.3)
The product is for research purpose only.
References
- 1)Synthesis and development of GO-Y030
- 2)Applications of GO-Y030 as an antitumor agent
- a)B. Hutzen, L. Friedman, M. Sobo, L. Lin, L. Cen, S. De Angelis, H. Yamakoshi, H. Shibata, Y. Iwabuchi, J. Lin, Int. J. Oncol. 2009, 35, 867.
- b)L. Lin, Y. Liu, H. Li, P.-K. Li, J. Fuchs, H. Shibata, Y. Iwabuchi, J. Lin, Br. J. Cancer 2011, 105, 212.
- c)A. Sato, C. Kudo, H. Yamakoshi, Y. Uehara, H. Ohori, C. Ishioka, Y. Iwabuchi, H. Shibata, Cancer Sci. 2011, 102, 1045.
- d)C. Kudo, H. Yamakoshi, A. Sato, H. Ohori, C. Ishioka, Y. Iwabuchi, H. Shibata, Anticancer Res. 2011, 31, 3719.
- a)B. Hutzen, L. Friedman, M. Sobo, L. Lin, L. Cen, S. De Angelis, H. Yamakoshi, H. Shibata, Y. Iwabuchi, J. Lin, Int. J. Oncol. 2009, 35, 867.
- 3)Structure activity relationships on the antitumor GO-Y030
Related Compounds
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