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Cyclin-Dependent Kinases Inhibitor
No.167(October 2015)

Kenpaullon (1) is a cell-permeable inhibitor of several cyclin-dependent kinases, CDK1/cyclin B, CDK2/cyclin A, CDK2/cyclin E and CDK5/p35, as shown in the Table.1) 1 also inhibits GSK3β.1,2)
1 is also utilized for establishing induced pluripotent stem cells (iPSCs) as one of the chemical “substitutes” of Klf4, which is one of four transcription factors (Oct4, Klf4, Sox2, and c-Myc).3)
ALS (amyotrophic lateral sclerosis) is a neurodegenerative disease caused by motor neuron death. Rubin et al. found that 1 promoted the survival of motor neurons by using human ALS iPSCs and ES Cells derived from an ALS model mouse.4)
Table. Inhibition of selected protein kinases by kenpaullone1)

This product is for research purpose only.
References
- 1)Discovery and initial characterization of the paullones, a novel class of small-molecule inhibitors of cyclin-dependent kinases
- 2)The specificities of protein kinase inhibitors: An update
- 3)Reprogramming of murine fibroblasts to induced pluripotent stem cells with chemical complementation of Klf4
- 4)A small molecule screen in stem-cell-derived motor neurons identifies a kinase inhibitor as a candidate therapeutic for ALS
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