Chlorotris(trimethylsilyl)silane (1) is a reagent for the introduction of tris(trimethylsilyl)silyl group (TTMSS group) as a protecting group. 1 reacts with primary or secondary alcohols in the presence of DMAP to give the corresponding TTMSS ethers in high yields.1) TTMSS ethers are stable to Grignard reagents, oxidation and acidic conditions. They are also stable to CsF, conditions under which cleavage of silyl ethers is often observed. TTMSS ethers can be cleaved with photolysis (254 nm) or by the action of TBAF.
Furthermore, in the Mukaiyama cross-aldol reaction2) and the [2+2] cyclization with acrylates3) using silyl enol ethers, the corresponding products can be obtained in high yields with high diastereoselectivity by the introduction of TTMSS group.
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