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Olefin Metathesis Catalyst
No.104(October 1999)
- B2036
- (Benzylidene)bis(tricyclohexylphosphine)ruthenium(IV) Dichloride (1)

Recently, olefin metathesis reaction employing metallic carbene complex as a catalyst is attracting a high degree of attention. Metathesis is referred to as a reaction in which an exchange of alkylidene group occurs between two olefin molecules.
In 1995 R.H. Grubbs and co-workers have developed the present reagent 1, as a metathesis catalyst. The catalyst 1 is characterized by being stable toward the oxygen and moisture in the atmosphere and inert to the presence of a variety of functional groups when compared with the conventional metathesis catalysts. The reactions using the catalyst 1 are mainly classified into ring-closing metathesis reaction and ring-opening cross metathesis reaction.
In 1995 R.H. Grubbs and co-workers have developed the present reagent 1, as a metathesis catalyst. The catalyst 1 is characterized by being stable toward the oxygen and moisture in the atmosphere and inert to the presence of a variety of functional groups when compared with the conventional metathesis catalysts. The reactions using the catalyst 1 are mainly classified into ring-closing metathesis reaction and ring-opening cross metathesis reaction.

A great number of synthesis examples employing the catalyst 1 for metathesis reactions, have been reported2) and its application toward synthesizing physiologically active substances have been increasingly carried out. For example, T. Oishi and co-workers have applied the catalyst 1 to the synthesis of polycyclic ethers3) and K. C. Nicolau and co-workers utilized the catalyst 1 in the synthesis of epothilones A and B4).
References
- 1)Well-defined metathesis catalysts
- 2)Olefin metathesis catalyst
- a)S. J. Miller, H. E. Blackwell, R. H. Grubbs, J. Am. Chem. Soc. 1996, 118, 9606.
- b)M. L. Snapper, J. A. Tallarico, M. L. Randall, ibid. 1997, 119, 1478.
- c)A. Furstner, K. Langemann, ibid. 1997, 119, 9130.
- d)F. P. J. T. Rutjes, H. E. Schoemaker, Tetrahedron Lett. 1997, 38, 677.
- e)S. E. Gibson, V. C. Gibson, S. P. Keen, Chem. Commun. 1997, 1107.
- a)S. J. Miller, H. E. Blackwell, R. H. Grubbs, J. Am. Chem. Soc. 1996, 118, 9606.
- 3)Synthesis of a trans-fused 6-7-6 tricyclic ether system
- 4)Synthesis of epothilones A and B in solid and solution phase K. C. Nicolaou, N. Winssinger, J. Pastor, S.
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