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Ubiquitin-Proteasome System (UPS) Research Reagents
Ubiquitin-Proteasome System (UPS) is an important system which regulates a number of signal transduction pathways and through which proteins are marked for proteasomal degradation by being linked to the polypeptide co-factor ubiquitin.
In the recent years, targeted protein degradation (TPD) using UPS to achieve knockdown of target proteins within cells (PROTAC, proteolysis targeting chimeras) became a useful drug discovery tool. 1,2)
E3 ubiquitin ligase inhibitors
Proteasome inhibitors
Deubiquitinating enzyme inhibitors
Related products3,4)
References
- 1) Protacs: Chimeric molecules that target proteins to the Skp1–Cullin–F box complex for ubiquitination and degradation
- 2) Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs
- 3) Protein knockdown using methyl bestatin-ligand hybrid molecules: design and synthesis of inducers of ubiquitination-mediated degradation of cellular retinoic acid-binding proteins
- 4) Reversible inhibitor of p97, DBeQ, impairs both ubiquitin-dependent and autophagic protein clearance pathways
