Tadalafil

Tadalafil is a selective inhibitor of cyclic guanosine monophosphate (cGMP) specific phosphodiesterase type 5 (PDE5) which is the predominant PDE isoenzyme in human corpora cavernosa, as with sildenafil [S0986, Citrate].^1,2) Although its chemical structure is significantly different from sildenafil, tadalafil shows significant potency for PDE5 inhibition. Current data suggest that PDE5 modulates distinct regulatory pathways in the cell. This property therefore offer the opportunity for selectively targeting specific PDE5 for treatment of specific disease states.²⁾ In fact, tadalafil is widely used also for the treatment of pulmonary arterial hypertension (PAH) which is a progressive disease that ultimately causes right heart failure and death.³⁾ In addition, tadalafil has been reported in some cases to be contained in adulterated food supplements, and methods for its detection are being developed.^4,5) (The product is for research purpose only.)