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CAS RN: 173903-47-4 | Product Number: T3862
Tizoxanide
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Purity: >95.0%(HPLC)
Synonyms:
- 2-Hydroxy-N-(5-nitro-2-thiazolyl)benzamide
Product Documents:
| Size | Unit Price | Hyderabad | Japan* | Quantity |
|---|---|---|---|---|
| 25MG |
₹4,900.00
|
4 | 33 |
|
| 100MG |
₹11,800.00
|
3 | 22 |
|
*Upon orders receipt, Hyderabad stocks will be dispatched on the same day.
*Items available in Japan warehouse will be dispatched in 10-12 working days.
*INR price is exclusive of domestic taxes applicable.
*TCI frequently reviews storage conditions to optimize them. Please note that the latest information on the storage temperature for the products is described on our website.
Supplemental Product Information:
This product is a sample for RUO (research use only). Do not use this product for any purpose other than testing and research.
| Product Number | T3862 |
| Purity / Analysis Method | >95.0%(HPLC) |
| Molecular Formula / Molecular Weight | C__1__0H__7N__3O__4S = 265.24 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Refrigerated (0-10°C) |
| Condition to Avoid | Heat Sensitive |
| CAS RN | 173903-47-4 |
| Reaxys Registry Number | 8324260 |
| PubChem Substance ID | 468592989 |
| MDL Number | MFCD07484970 |
Specifications
| Appearance | White to Orange to Green powder to crystal |
| Purity(HPLC) | min. 95.0 area% |
| Elemental analysis(Nitrogen) | 15.10 to 16.60 % |
Properties (reference)
| Melting Point | 254 °C |
GHS
| Pictogram |
|
| Signal Word | Warning |
| Hazard Statements | H315 : Causes skin irritation. H319 : Causes serious eye irritation. |
| Precautionary Statements | P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ eye protection/ face protection. P302 + P352 : IF ON SKIN: Wash with plenty of water. P337 + P313 : If eye irritation persists: Get medical advice/ attention. P305 + P351 + P338 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P362 + P364 : Take off contaminated clothing and wash it before reuse. P332 + P313 : If skin irritation occurs: Get medical advice/ attention. |
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Transport Information:
Application
Tizoxanide: An Active Metabolite of Nitazoxanide, a Thiazolide Antiprotozoal and Antiviral Agent
Tizoxanide is an active metabolite of nitazoxanide [N1031] which is originally developed as a thiazolide antiprotozoal agent that shows excellent in vitro activity against a variety of microorganisms, including a broad range of protozoa and helminths.1,2) Following oral administration in animals, nitazoxanide is rapidly hydrolyzed to tizoxanide (desacetyl-nitazoxanide) by esterase. The antiprotozoal activity of tizoxanide is believed to be due to interference with the pyruvate:ferredoxin oxidoreductase (PFOR) enzyme-dependent electron transfer reaction which is essential to anaerobic energy metabolism. Recently, antiviral activity of nitazoxanide (tizoxanide) against a broad range of other RNA and DNA viruses such as hepatitis B virus, hepatitis C virus and influenza virus has been recognized in in vitro systems.3-5) Nitazoxanide (tizoxanide) is synergistic with neuraminidase inhibitors, and also inhibits the replication of a broad range of viruses. (The product is for research purpose only.)
References
- 1) In vitro evaluation of activities of nitazoxanide and tizoxanide against anaerobes and aerobic organisms
- 2) In vitro activity of nitazoxanide and related compounds against isolates of Giardia intestinalis, Entamoeba histolytica and Trichomonas vaginalis
- 3) Nitazoxanide, tizoxanide and other thiazolides are potent inhibitors of hepatitis B virus and hepatitis C virus replication
- 4) Thiazolides, a new class of anti-influenza molecules targeting viral hemagglutinin at the post-translational level
- 5) Antiviral activity of substituted salicylanilides - a review
Application
Tizoxanide: An Active Metabolite of Antiprotozoal Nitazoxanide
Tizoxanide is an active metabolite of nitazoxanide [N1031] which is a thiazolide antiprotozoal agent. The antiprotozoal activity of tizoxanide is believed to be due to interference with the pyruvate:ferredoxin oxidoreductase (PFOR) enzyme-dependent electron transfer reaction which is essential to anaerobic energy metabolism. (The product is for research purpose only.)
References
- Nitazoxanide: pharmacokinetics and metabolism in man
- The pharmacokinetics of nitazoxanide active metabolite (tizoxanide) in goats and its protein binding ability in vitro
- Validated and Optimized High-Performance Liquid Chromatographic Determination of Tizoxanide, the Main Active Metabolite of Nitazoxanide in Human Urine, Plasma and Breast Milk
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