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CAS RN: 122292-85-7 | Product Number: T3633
(-)-Trichostatin A
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Purity: >98.0%(HPLC)
Synonyms:
- [S-(E,E)]-(-)-7-[4-(Dimethylamino)phenyl]-N-hydroxy-4,6-dimethyl-7-oxo-2,4-heptadienamide
Product Documents:
| Size | Unit Price | Hyderabad | Japan* | Quantity |
|---|---|---|---|---|
| 10MG |
₹10,200.00
|
Contact Us | ≥100 |
|
*Upon orders receipt, Hyderabad stocks will be dispatched on the same day.
*Items available in Japan warehouse will be dispatched in 10-12 working days.
*INR price is exclusive of domestic taxes applicable.
*TCI frequently reviews storage conditions to optimize them. Please note that the latest information on the storage temperature for the products is described on our website.
| Product Number | T3633 |
| Purity / Analysis Method | >98.0%(HPLC) |
| Molecular Formula / Molecular Weight | C__1__7H__2__2N__2O__3 = 302.37 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Frozen (<0°C) |
| Condition to Avoid | Heat Sensitive |
| CAS RN | 122292-85-7 |
| Reaxys Registry Number | 5291762 |
| PubChem Substance ID | 354334997 |
Specifications
| Appearance | White to Orange to Green powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Optical purity(LC) | min. 95.0 ee% |
Properties (reference)
| Specific Rotation | -133° (C=0.3,MeOH) |
GHS
| Pictogram |
|
| Signal Word | Warning |
| Hazard Statements | H302 + H312 + H332 : Harmful if swallowed, in contact with skin or if inhaled. H315 : Causes skin irritation. H319 : Causes serious eye irritation. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P261 : Avoid breathing dust/ fume/ gas/ mist/ vapors/ spray. P270 : Do not eat, drink or smoke when using this product. P271 : Use only outdoors or in a well-ventilated area. P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection. P337 + P313 : If eye irritation persists: Get medical advice/ attention. P305 + P351 + P338 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P362 + P364 : Take off contaminated clothing and wash it before reuse. P332 + P313 : If skin irritation occurs: Get medical advice/ attention. P301 + P312 + P330 : IF SWALLOWED: Call a POISON CENTER/doctor if you feel unwell. Rinse mouth. P302 + P352 + P312 : IF ON SKIN: Wash with plenty of water.Call a POISON CENTER/doctor if you feel unwell. P304 + P340 + P312 : IF INHALED: Remove person to fresh air and keep comfortable for breathing. Call a POISON CENTER/doctor if you feel unwell. |
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Application
(-)-Trichostatin A: The Less Active Enantiomer of Trichostatin A
(-)-Trichostatin A (S-enantiomer) is the less active enantiomer (distomer) of trichostatin A (R-enantiomer) [T2477] as a HDAC inhibitor. However, it has been reported that HDAC inhibition assays with R- and S-trichostatin A in 2016 showed that the R-enantiomer was a broad-range HDAC inhibitor, whereas the S-enantiomer had moderate selectivity for HDAC6.
References
- Structural specificity for biological activity of trichostatin A, a specific inhibitor of mammalian cell cycle with potent differentiation-inducing activity in Friend leukemia cells
- Modulation of growth and differentiation of human colon carcinoma cells by histone deacetylase inhibitory trichostatins
- Structural insights into HDAC6 tubulin deacetylation and its selective inhibition
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