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CAS RN: 322-79-2 | Product Number: T3601

Triflusal


Purity: >98.0%(T)
Synonyms:
  • Acetyl-4-(trifluoromethyl)salicylic Acid
  • 2-Acetoxy-4-(trifluoromethyl)benzoic Acid
  • Drisgen
Product Documents:
250MG
₹7,700.00
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1G
₹13,200.00
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Product Number T3601
Purity / Analysis Method >98.0%(T)
Molecular Formula / Molecular Weight C__1__0H__7F__3O__4 = 248.16 
Physical State (20 deg.C) Solid
Storage Temperature Refrigerated (0-10°C)
Condition to Avoid Heat Sensitive
CAS RN 322-79-2
Reaxys Registry Number 2945374
PubChem Substance ID 354335089
Merck Index (14) 9688
MDL Number

MFCD00866793

Specifications
Appearance White to Almost white powder to crystal
Purity(GC) min. 96.0 %
Purity(Neutralization titration) min. 98.0 %
Melting point 113.0 to 117.0 °C
NMR confirm to structure
Properties (reference)
Melting Point 115 °C
Maximum Absorption Wavelength 297 nm (H__2O)
Solubility in water Insoluble
GHS
Pictogram Pictogram
Signal Word Warning
Hazard Statements H302 : Harmful if swallowed.
H315 : Causes skin irritation.
H319 : Causes serious eye irritation.
Precautionary Statements P501 : Dispose of contents/ container to an approved waste disposal plant.
P270 : Do not eat, drink or smoke when using this product.
P264 : Wash skin thoroughly after handling.
P280 : Wear protective gloves/ eye protection/ face protection.
P302 + P352 : IF ON SKIN: Wash with plenty of water.
P337 + P313 : If eye irritation persists: Get medical advice/ attention.
P305 + P351 + P338 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P362 + P364 : Take off contaminated clothing and wash it before reuse.
P332 + P313 : If skin irritation occurs: Get medical advice/ attention.
P301 + P312 + P330 : IF SWALLOWED: Call a POISON CENTER/doctor if you feel unwell. Rinse mouth.
Related Laws:
Transport Information:
Application
Triflusal: An Antiplatelet Aggregation Agent

Triflusal is an antiplatelet aggregation agent having a trifluoromethyl group at the 4-position. It is metabolized to 2-hydroxy-4-trifluoromethylbenzoic acid (HTB) which inhibits cyclogxygenase-1 (COX-1) in platelets. Furthermore, both triflusal and HTB are also able to increase cyclic adenosine monophosphate (cAMP) [A2381] levels in platelets through inhibition of platelet phosphodiesterases which regulate intracellular cAMP levels. Moreover, triflusal enhances the production of NO by neutrophils via stimulation of the constitutive activity of nitric oxide (NO) synthase (cNOS). It is considered that triflusal shows the antiplatelet aggregation activity by these actions. (The product is for research purpose only.)

References


PubMed Literature


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