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CAS RN: 5690-03-9 | Product Number: S0892
Splitomicin
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Purity: >98.0%(GC)
Synonyms:
- 1,2-Dihydro-3H-naphtho[2,1-b]pyran-3-one
Product Documents:
| Size | Unit Price | Hyderabad | Japan* | Quantity |
|---|---|---|---|---|
| 200MG |
₹7,800.00
|
Contact Us | 5 |
|
| 1G |
₹17,500.00
|
1 | 12 |
|
*Upon orders receipt, Hyderabad stocks will be dispatched on the same day.
*Items available in Japan warehouse will be dispatched in 10-12 working days.
*INR price is exclusive of domestic taxes applicable.
*TCI frequently reviews storage conditions to optimize them. Please note that the latest information on the storage temperature for the products is described on our website.
| Product Number | S0892 |
| Purity / Analysis Method | >98.0%(GC) |
| Molecular Formula / Molecular Weight | C__1__3H__1__0O__2 = 198.22 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Refrigerated (0-10°C) |
| Store Under Inert Gas | Store under inert gas |
| Condition to Avoid | Air Sensitive,Heat Sensitive |
| CAS RN | 5690-03-9 |
| Reaxys Registry Number | 161649 |
| PubChem Substance ID | 172089098 |
| MDL Number | MFCD08705254 |
Specifications
| Appearance | White to Almost white powder to crystal |
| Purity(GC) | min. 98.0 % |
| Melting point | 53.0 to 57.0 °C |
Properties (reference)
| Melting Point | 55 °C |
GHS
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Application
Splitomicin: A Potent Selective Inhibitor of Silent Information Regulator-2 (Sir2)
Silent Information Regulator-2 (Sir2) is a one of Class III histone deacetylases (HDACs) called Sirtuins. Splitomicin, which is derived from β-naphthol, is a potent selective inhibitor of Sir2. It inhibits nicotinamide adenine dinucleotide+ (NAD+) dependent histone deacetylase activity of Sir2.
References
- Identification of a small molecule inhibitor of Sir2p
- Identification of selective inhibitors of NAD+-dependent deacetylases using phenotypic screens in yeast
- Inhibitors of Sir2: Evaluation of Splitomicin Analogues
- Splitomicin suppresses human platelet aggregation via inhibition of cyclic AMP phosphodiesterase and intracellular Ca++ release
- Splitomicin inhibits fMLP-induced superoxide anion production in human neutrophils by activate cAMP/PKA signaling inhibition of ERK pathway
PubMed Literature
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