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Maximum quantity allowed is 999
CAS RN: | Product Number: R0275
Reagents for Suzuki-Miyaura Cross-Coupling Reactions [Pd(dppf)Cl2·CH2Cl2, Cs2CO3] (HPMC encapsulated)
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Purity:
- Pd(dppf)Cl2·CH2Cl2 ca. 0.03 mmol/capsule, Cs2CO3 ca. 0.7 mmol/capsule (HPMC encapsulated)
| Size | Unit Price | Hyderabad | Japan* | Quantity |
|---|---|---|---|---|
| 10EACH |
₹10,350.00
|
Contact Us | ≥40 |
|
*Upon orders receipt, Hyderabad stocks will be dispatched on the same day.
*Items available in Japan warehouse will be dispatched in 10-12 working days.
*INR price is exclusive of domestic taxes applicable.
*TCI frequently reviews storage conditions to optimize them. Please note that the latest information on the storage temperature for the products is described on our website.
Supplemental Product Information:
Contents (per one capsule)
- Pd(dppf)Cl2·CH2Cl2 : ca. 0.03 mmol
- Cs2CO3 : ca. 0.7 mmol
Directions for Use
- Each capsule contains all reagents for a single use on 0.60 mmol scale Suzuki-Miyaura Cross-Coupling Reactions. Typical condition: 0.60 mmol of aryl halide and 1.5 equiv of boronic acid in THF/water (4:1) (0.30 M) at 100 °C.
(Reference: J. Org. Chem. 2021, 86, 1357.)
Related Products
- B2064 [1,1'-Bis(diphenylphosphino)ferrocene]palladium(II) Dichloride Dichloromethane Adduct (= Pd(dppf)Cl2·CH2Cl2)
- C2160 Cesium Carbonate (= Cs2CO3)
| Product Number | R0275 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Refrigerated (0-10°C) |
| Store Under Inert Gas | Store under inert gas |
| Condition to Avoid | Air Sensitive |
| Appearance | White to Light yellow to Light orange capsule |
| Functionality test (conversion ratio) | min. 90.0 % |
| Pictogram |
|
| Signal Word | Danger |
| Hazard Statements | H318 : Causes serious eye damage. H361 : Suspected of damaging fertility or the unborn child. H373 : May cause damage to organs through prolonged or repeated exposure. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P260 : Do not breathe dust/ fume/ gas/ mist/ vapors/ spray. P202 : Do not handle until all safety precautions have been read and understood. P201 : Obtain special instructions before use. P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection. P308 + P313 : IF exposed or concerned: Get medical advice/ attention. P305 + P351 + P338 + P310 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Immediately call a POISON CENTER/doctor. P405 : Store locked up. |
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Used Chemicals
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Procedure
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Reagents for Suzuki-Miyaura Cross-Coupling Reactions (one capsule) was added to a solution of 2-acetamido-5-bromo-4-methylpyridine (137 mg, 0.60 mmol) and phenylboronic acid (110 mg, 0.90 mmol, 1.5 eq.) in THF/H2O (4:1, 2 mL) at r.t. and the reaction mixture was stirred at 100 °C for 2 hours. The solution was then filtered through Celite pad and the filtrate was diluted with sat. Na2SO4 aq. (15 mL). The aqueous layer was extracted with ethyl acetate (15 mL x 2) and the organic layer was washed with water (15 mL) and brine (15 mL), dried over sodium sulfate and concentrated under reduced pressure. The crude product was purified by silica gel chromatography (ethyl acetate:hexane = 2:1 - 1:4) and then further purified by reversed-phase silica gel chromatography (water:acetonitrile = 95:5 - 40:60) to afford 2-acetamido-4-methyl-5-phenylpyridine (122 mg, 90% yield) as a white solid.
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Experimenter’s Comments
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The reaction mixture was monitored by GC.
The shape of the capsule is like below image and Pd(dppf)Cl2·CH2Cl2 (ca. 0.03 mmol) and Cs2CO3 (ca. 0.7 mmol) are encapsulated in each capsule.
The material of the capsule is water-soluble HPMC (hydroxypropyl methylcellulose).
Since it was difficult to remove the starting material by the normal phase silica gel column purification, so the reverse-phase column purification was performed.
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Analytical Data
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2-Acetamido-4-methyl-5-phenylpyridine
1H NMR (400 MHz, CDCl3); δ 9.24-9.06 (brs, 1H), 8.16 (s, 1H), 8.10 (s, 1H), 7.46-7.36 (m, 3H), 7.30-7.29 (m, 2H), 2.32 (s, 3H), 2.21 (s, 3H).
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Lead Reference
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- Reagent and Catalyst Capsules: A Chemical Delivery System for Reaction Screening and Parallel Synthesis
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Other Reference
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- HPMC: A Biomass-Based Semisynthetic Sustainable Additive Enabling Clean and Fast Chemistry in Water
Articles/Brochures
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