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CAS RN: 123441-03-2 | Product Number: R0250
Rivastigmine
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Purity: >98.0%(HPLC)
Synonyms:
- (S)-3-[1-(Dimethylamino)ethyl]phenyl Ethyl(methyl)carbamate
- Ethylmethylcarbamic Acid 3-[(S)-1-(Dimethylamino)ethyl]phenyl Ester
Product Documents:
| Size | Unit Price | Hyderabad | Japan* | Quantity |
|---|---|---|---|---|
| 1G |
₹16,200.00
|
4 | 39 |
|
*Upon orders receipt, Hyderabad stocks will be dispatched on the same day.
*Items available in Japan warehouse will be dispatched in 10-12 working days.
*INR price is exclusive of domestic taxes applicable.
*TCI frequently reviews storage conditions to optimize them. Please note that the latest information on the storage temperature for the products is described on our website.
| Product Number | R0250 |
| Purity / Analysis Method | >98.0%(HPLC) |
| Molecular Formula / Molecular Weight | C__1__4H__2__2N__2O__2 = 250.34 |
| Physical State (20 deg.C) | Liquid |
| Storage Temperature | Refrigerated (0-10°C) |
| Store Under Inert Gas | Store under inert gas |
| Condition to Avoid | Air Sensitive,Heat Sensitive |
| CAS RN | 123441-03-2 |
| Reaxys Registry Number | 7875788 |
| PubChem Substance ID | 468592798 |
| MDL Number | MFCD00871496 |
Specifications
| Appearance | Colorless to Light yellow clear liquid |
| Purity(HPLC) | min. 98.0 area% |
| Specific rotation | -31.0 to -35.0deg (C=1, ethanol) |
| NMR | confirm to structure |
Properties (reference)
| Boiling Point | 135 °C/0.26 mmHg |
| Flash point | 145.0 °C |
| Specific Gravity (20/20) | 1.03 |
| Solubility in water | Slightly soluble |
| Solubility (miscible with) | Methanol, Ethanol |
GHS
| Pictogram |
|
| Signal Word | Danger |
| Hazard Statements | H301 : Toxic if swallowed. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P270 : Do not eat, drink or smoke when using this product. P264 : Wash skin thoroughly after handling. P301 + P310 + P330 : IF SWALLOWED: Immediately call a POISON CENTER/doctor. Rinse mouth. P405 : Store locked up. |
Related Laws:
| RTECS# | FA9546000 |
Transport Information:
| UN Number | UN2810 |
| Class | 6.1 |
| Packing Group | III |
Application
Rivastigmine: A Dual Inhibitor of Acetylcholinesterase (AChE) and Butyrylcholinesterase (BuChE)
Rivastigmine is an inhibitor of two cholinesterase enzymes, acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE). Rivastigmine activates central cholinergic nervous system by increasing the concentration of acetylcholine (ACh) in brain through reversible inhibition of its hydrolysis by AChE and BuChE. For comparison, another cholinesterase inhibitor, donepezil hydrochloride [D4099] shows high selectivity for AChE over BuChE. In clinical, its tartrate [R0093] is used for the treatment of Alzheimer’s disease. (The product is for research purpose only.)
References
- Comparison of inhibitory activities of donepezil and other cholinesterase inhibitors on acetylcholinesterase and butyrylcholinesterase in vitro
- Kinetic and Structural Studies on the Interaction of Cholinesterases with the Anti-Alzheimer Drug Rivastigmine
- Clinical pharmacokinetics and pharmacodynamics of cholinesterase inhibitors
- A review of rivastigmine: a reversible cholinesterase inhibitor
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