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CAS RN: 199864-86-3 | Product Number: R0221
RS-127445 Hydrochloride
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Purity: >98.0%(HPLC)
Synonyms:
- 4-(4-Fluoronaphthalen-1-yl)-6-isopropylpyrimidin-2-amine Hydrochloride
Product Documents:
| Size | Unit Price | Hyderabad | Japan* | Quantity |
|---|---|---|---|---|
| 10MG |
₹5,300.00
|
Contact Us | 4 |
|
| 50MG |
₹15,900.00
|
Contact Us | 13 |
|
*Upon orders receipt, Hyderabad stocks will be dispatched on the same day.
*Items available in Japan warehouse will be dispatched in 10-12 working days.
*INR price is exclusive of domestic taxes applicable.
*TCI frequently reviews storage conditions to optimize them. Please note that the latest information on the storage temperature for the products is described on our website.
| Product Number | R0221 |
| Purity / Analysis Method | >98.0%(HPLC) |
| Molecular Formula / Molecular Weight | C__1__7H__1__6FN__3·HCl = 317.79 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Refrigerated (0-10°C) |
| Store Under Inert Gas | Store under inert gas |
| Condition to Avoid | Air Sensitive,Heat Sensitive |
| CAS RN | 199864-86-3 |
| Reaxys Registry Number | 11735151 |
| PubChem Substance ID | 468592792 |
| MDL Number | MFCD11112196 |
Specifications
| Appearance | White to Orange to Green powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Elemental analysis(Nitrogen) | 12.60 to 13.80 % |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 158 °C |
GHS
| Pictogram |
|
| Signal Word | Warning |
| Hazard Statements | H315 : Causes skin irritation. H319 : Causes serious eye irritation. H413 : May cause long lasting harmful effects to aquatic life. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P273 : Avoid release to the environment. P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ eye protection/ face protection. P302 + P352 : IF ON SKIN: Wash with plenty of water. P337 + P313 : If eye irritation persists: Get medical advice/ attention. P305 + P351 + P338 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P362 + P364 : Take off contaminated clothing and wash it before reuse. P332 + P313 : If skin irritation occurs: Get medical advice/ attention. |
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Application
RS-127445 Hydrochloride: A Selective and Orally Bioavailable 5-HT2B Receptor Antagonist
RS-127445 hydrochloride is a selective and orally bioavailable 5-HT2B receptor antagonist which was at first developed for the prophylactic treatment of migraine. Recently, it has been reported that RS-127445 modulate visceral hypersensitivity. (The product is for research purpose only.)
References
- RS-127445: a selective, high affinity, orally bioavailable 5-HT2B receptor antagonist
- Inhibition of colonic motility and defecation by RS-127445 suggests an involvement of the 5-HT2B receptor in rodent large bowel physiology
- 5-HT2B receptors modulate visceral hypersensitivity in a stress-sensitive animal model of brain-gut axis dysfunction
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