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Product Document Searching Made Easy by 2D Code! | [Product Highlights] MTTP: A Powerful Electrophilic Trifluoromethylthiolating Reagent...

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CAS RN: 90098-04-7 | Product Number: R0085

Rebamipide

Purity: >98.0%(HPLC)

Synonyms:

2-(4-Chlorobenzamido)-3-[2(1H)-quinolinon-4-yl]propionic Acid

Product Documents:

Size	Unit Price	Hyderabad	Japan*
1G	₹3,900.00	Contact Us	2
5G	₹5,600.00	1	2
25G	₹13,300.00	2	≥60

*Upon orders receipt, Hyderabad stocks will be dispatched on the same day.
*Items available in Japan warehouse will be dispatched in 10-12 working days.
*INR price is exclusive of domestic taxes applicable.
*TCI frequently reviews storage conditions to optimize them. Please note that the latest information on the storage temperature for the products is described on our website.

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General Information plus

Specifications & Properties plus

Specifications

Appearance	White to Almost white powder to crystal
Purity(HPLC)	min. 98.0 area%
Purity(Neutralization titration)	min. 95.0 %

Properties (reference)

Melting Point

290 °C(dec.)

Safety & Regulations plus

GHS

Related Laws:

RTECS#

VC2518500

Transport Information:

Applications & Literature plus

Application

Rebamipide: A Quinolinone Analog for Gastric Mucosal Protection

Rebamipide (OPC-12759), a 2(1H)-quinolinone analog, is used as an anti-gastritis and anti-gastric ulcer agent. It has been reported to have various activities in the gastric mucosa, such as stimulation of prostaglandin and mucus glycoprotein synthesis, inhibition of reactive oxygen species, inflammatory cytokines and chemokines, and inhibition of neutrophils activation. Furthermore, inhibition of gastric tumor growth by rebamipide has also been reported. In addition, rebamipide is used as a therapeutic adjunct for the treatment of infections caused by Helicobacter pylori. For your reference, we also have a related synthetic intermediate [O0468] of rebamipide. (The product is for research purpose only.)

References

Studies on 2 (1H)-Quinolinone Derivatives as Gastric Antiulcer Active Agents. 2-(4-Chlorobenzoylamino)-3-[2 (1H)-quinolinon-4-yl] propionic Acid and Related Compounds
- M. Uchida, F. Tabusa, M. Komatsu, S. Morita, T. Kanbe, K. Nakagawa, Chem. Pharm. Bull. 1985, 33, 3775.
Gastric mucosal protection by OPC-12759, a novel antiulcer compound, in the rat
- K. Yamasaki, T. Kanbe, T. Chijiwa, H. Ishiyama, S. Morita, Eur. J. Pharmacol. 1987, 142, 23.
Hydroxyl radical scavenging by rebamipide and related compounds: electron paramagnetic resonance study
- Y. Naito, T. Yoshikawa, T. Tanigawa, K. Sakurai, K. Yamasaki, M. Uchida, M. Kondo, Free Radical Biol. Med. 1995, 18, 117.
15th Anniversary of Rebamipide: Looking Ahead to the New Mechanisms and New Applications (a review)
- T. Arakawa, K. Higuchi, Y. Fujiwara, T. Watanabe, K. Tominaga, E. Sasaki, N. Oshitani, T. Yoshikawa, A. S. Tarnawski, Dig. Dis. Sci. 2005, 50, S3.
Rebamipide: a gastrointestinal protective drug with pleiotropic activities (a review)
- Y. Naito, T. Yoshikawa, Expert Rev. Gastroenterol. Hepatol. 2010, 4, 261.
Optimization of forced degradation using experimental design and development of a stability-indicating liquid chromatographic assay method for rebamipide in bulk and tablet dosage form
- S. Sonawane, P. Gide, Sci. Pharm. 2011, 79, 85.

Application

Induction of Cyclooxygenase-2 (COX-2) in Rat Gastric Mucosa by Rebamipide

Reference

Induction of Cyclooxygenase-2 in Rat Gastric Mucosa by Rebamipide, a Mucoprotective Agent
- M. Yasumaru, H. Iijima, Y. Okuda, Y. Sasaki, M. Hori, S. Kawano, J. Pharmacol. Exp. Ther. 2000, 295, 447.

PubMed Literature

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Pharmaceutical Ingredients for Research and Experimental Use

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Product Number	R0085
Purity / Analysis Method	>98.0%(HPLC)
Molecular Formula / Molecular Weight	C__1__9H__1__5ClN__2O__4 = 370.79
Physical State (20 deg.C)	Solid
Storage Temperature	Room Temperature (Recommended in a cool and dark place, <15°C)
CAS RN	90098-04-7
Reaxys Registry Number	5384689
PubChem Substance ID	125307349
Merck Index (14)	8124
MDL Number	MFCD11114396

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CAS RN: 90098-04-7 | Product Number: R0085