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CAS RN: 459789-99-2 | Product Number: O0641
Obeticholic Acid
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Purity: >97.0%(GC)(T)
Synonyms:
- 6-ECDCA
- 6-Ethylchenodeoxycholic Acid
- 6-Ethyl-3α,7α-dihydroxycholan-24-oic Acid
Product Documents:
| Size | Unit Price | Hyderabad | Japan* | Quantity |
|---|---|---|---|---|
| 1G |
₹9,500.00
|
Contact Us | Contact Us |
|
*Upon orders receipt, Hyderabad stocks will be dispatched on the same day.
*Items available in Japan warehouse will be dispatched in 10-12 working days.
*INR price is exclusive of domestic taxes applicable.
*TCI frequently reviews storage conditions to optimize them. Please note that the latest information on the storage temperature for the products is described on our website.
| Product Number | O0641 |
| Purity / Analysis Method | >97.0%(GC)(T) |
| Molecular Formula / Molecular Weight | C__2__6H__4__4O__4 = 420.63 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Refrigerated (0-10°C) |
| Condition to Avoid | Heat Sensitive |
| CAS RN | 459789-99-2 |
| Reaxys Registry Number | 9238543 |
| MDL Number | MFCD16621104 |
Specifications
| Appearance | White to Light yellow powder to crystal |
| Purity(GC) | min. 97.0 % |
| Purity(Neutralization titration) | min. 97.0 % |
| Melting point | 106.0 to 110.0 °C |
| Specific rotation | +3.3 to +5.5 deg(C=1, methanol) |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 109 °C |
GHS
Related Laws:
| RTECS# | FZ2267000 |
Transport Information:
Application
Obeticholic Acid: A Potent and Selective Agonist of Farnesoid X Receptor (FXR)
Farnesoid X receptor (FXR), a nuclear receptor, is a ligand-activated transcription factor involved in the control of bile acid (BA) synthesis and enterohepatic circulation, and a regulator of glucose and lipid metabolism. Obeticholic acid (6-ECDCA, INT-747) is a semi-synthetic mimetic of the primary human bile acid, chenodeoxycholic acid (CDCA) [C0750]. There are reports that obeticholic acid is a potent and selective activator of FXR that reduces hepatic steatosis and fibrosis in animal models of fatty liver disease. (The product is for research purpose only.)
References
- 6α-Ethyl-Chenodeoxycholic Acid (6-ECDCA), a Potent and Selective FXR Agonist Endowed with Anticholestatic Activity
- Ursodeoxycholic acid and bile-acid mimetics as therapeutic agents for cholestatic liver diseases: An overview of their mechanisms of action (a review)
- The role of farnesoid X receptor in metabolic diseases, and gastrointestinal and liver cancer (a review)
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