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CAS RN: 128607-22-7 | Product Number: O0441
Ospemifene
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Purity: >98.0%(GC)
Synonyms:
Product Documents:
| Size | Unit Price | Hyderabad | Japan* | Quantity |
|---|---|---|---|---|
| 100MG |
₹8,000.00
|
5 | 17 |
|
| 1G |
₹31,900.00
|
1 | 32 |
|
*Upon orders receipt, Hyderabad stocks will be dispatched on the same day.
*Items available in Japan warehouse will be dispatched in 10-12 working days.
*INR price is exclusive of domestic taxes applicable.
*TCI frequently reviews storage conditions to optimize them. Please note that the latest information on the storage temperature for the products is described on our website.
| Product Number | O0441 |
| Purity / Analysis Method | >98.0%(GC) |
| Molecular Formula / Molecular Weight | C__2__4H__2__3ClO__2 = 378.90 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Refrigerated (0-10°C) |
| Condition to Avoid | Heat Sensitive |
| CAS RN | 128607-22-7 |
| Reaxys Registry Number | 10283864 |
| PubChem Substance ID | 253662436 |
| MDL Number | MFCD00871890 |
Specifications
| Appearance | White to Almost white powder to crystal |
| Purity(GC) | min. 98.0 % |
Properties (reference)
GHS
| Pictogram |
|
| Signal Word | Warning |
| Hazard Statements | H361 : Suspected of damaging fertility or the unborn child. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P202 : Do not handle until all safety precautions have been read and understood. P201 : Obtain special instructions before use. P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection. P308 + P313 : IF exposed or concerned: Get medical advice/ attention. P405 : Store locked up. |
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Application
選択的エストロゲン受容体調節剤 (SERM)，オスペミフェン
Ospemifene (FC1271a) was first reported as a metabolite of toremifene [T2832] which is an antiestrogen and a hormonal antitumor agent. Ospemifene is the first non-hormonal estrogen receptor agonist/antagonist or selective estrogen receptor modulator (SERM). It specifically binds to the estrogen receptor α and β with affinity closely similar to that of toremifene and tamoxifen [T2510]. Ospemifene is currently used for treatment of vulvovaginal atrophy (VVA). In addition, the antiestrogenic activity of ospemifene in several breast cancer animal models has been reported. (The product is for research purpose only.)
References
- Metabolism of toremifene in the rat
- Selective estrogenic effects of a novel triphenylethylene compound, FC1271a, on bone, cholesterol level, and reproductive tissues in intact and ovariectomized rats
- Pharmacokinetics of selective estrogen receptor modulators (a review)
- Selective estrogen receptor modulators for postmenopausal osteoporosis: current state of development (a review)
- Tissue selectivity of ospemifene: Pharmacologic profile and clinical implications (a review)
- Ospemifene, vulvovaginal atrophy, and breast cancer (a review)
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