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CAS RN: 63675-72-9 | Product Number: N0900
Nisoldipine
×
Purity: >98.0%(HPLC)(N)
Synonyms:
- 1,4-Dihydro-2,6-dimethyl-4-(2-nitrophenyl)-3,5-pyridinedicarboxylic Acid Isobutyl Methyl Ester
- Isobutyl Methyl 1,4-Dihydro-2,6-dimethyl-4-(2-nitrophenyl)-3,5-pyridinedicarboxylate
Product Documents:
| Size | Unit Price | Hyderabad | Japan* | Quantity |
|---|---|---|---|---|
| 1G |
₹7,000.00
|
1 | 1 |
|
| 5G |
₹10,500.00
|
1 | 10 |
|
*Upon orders receipt, Hyderabad stocks will be dispatched on the same day.
*Items available in Japan warehouse will be dispatched in 10-12 working days.
*INR price is exclusive of domestic taxes applicable.
*TCI frequently reviews storage conditions to optimize them. Please note that the latest information on the storage temperature for the products is described on our website.
| Product Number | N0900 |
Purity / Analysis Method 
|
>98.0%(HPLC)(N) |
| Molecular Formula / Molecular Weight | C__2__0H__2__4N__2O__6 = 388.42 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature
|
Room Temperature (Recommended in a cool and dark place, <15°C) |
| Packaging and Container
|
1G-Glass Bottle with Plastic Insert (View image) |
| CAS RN | 63675-72-9 |
| Reaxys Registry Number | 454188 |
| PubChem Substance ID | 160871273 |
| Merck Index (14) | 6565 |
| MDL Number | MFCD00478055 |
Specifications
| Appearance | Light yellow to Amber to Dark green powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(with Total Nitrogen) | min. 98.0 % |
| Melting point | 148.0 to 154.0 °C |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 153 °C |
| Solubility in water | Insoluble |
| Solubility (soluble in) | Methanol |
GHS
| Pictogram |
|
| Signal Word | Warning |
| Hazard Statements | H302 + H312 + H332 : Harmful if swallowed, in contact with skin or if inhaled. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P261 : Avoid breathing dust/ fume/ gas/ mist/ vapors/ spray. P270 : Do not eat, drink or smoke when using this product. P271 : Use only outdoors or in a well-ventilated area. P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ protective clothing. P362 + P364 : Take off contaminated clothing and wash it before reuse. P301 + P312 + P330 : IF SWALLOWED: Call a POISON CENTER/doctor if you feel unwell. Rinse mouth. P302 + P352 + P312 : IF ON SKIN: Wash with plenty of water.Call a POISON CENTER/doctor if you feel unwell. P304 + P340 + P312 : IF INHALED: Remove person to fresh air and keep comfortable for breathing. Call a POISON CENTER/doctor if you feel unwell. |
Related Laws:
| RTECS# | US7975600 |
Transport Information:
Application
長時間作動型のジヒドロピリジン系L型Ca2+チャンネル受容体アンタゴニスト，
Nisoldipine is a dihydropyridine-derivative L-type Ca2+ channel receptor antagonist which relaxes arterial smooth muscle with high vascular selectivity and without changing serum calcium concentrations. This leads to prolonged vascular relaxation and lowering of blood pressure. In comparison with nifedipine [N0528], nisoldipine have a longer duration of action. Nisoldipine is mainly metabolized by CYP3A4 in the liver. In addition, nisoldipine coat-core (CC) has been developed extended-release formulation that provides sustained 24-h blood pressure control. (The product is for research purpose only.)
References
- Voltage-dependent block of calcium channel current in the calf cardiac Purkinje fiber by dihydropyridine calcium channel antagonists
- Increase in survival time of liver transplants by protease inhibitors and a calcium channel blocker, nisoldipine
- Crystal structures and pharmacologic activities of 1,4-dihydropyridine calcium channel antagonists of the isobutyl methyl 2,6-dimethyl-4-(substituted phenyl)-1,4-dihydropyridine-3,5-dicarboxylate (nisoldipine) series
- Clinical pharmacokinetics of nisoldipine coat-core (a review)
PubMed Literature
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