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CAS RN: 75530-68-6 | Product Number: N0899

Nilvadipine

Chemical Structure of Nilvadipine

Purity: >95.0%(N)
Synonyms:
  • 2-Cyano-1,4-dihydro-6-methyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic Acid 5-Isopropyl 3-Methyl Ester
  • 5-Isopropyl 3-Methyl 2-Cyano-1,4-dihydro-6-methyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylate
Product Documents:
1G
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5G
₹15,000.00
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Product Number N0899
Purity / Analysis Method >95.0%(N)
Molecular Formula / Molecular Weight C__1__9H__1__9N__3O__6 = 385.38 
Physical State (20 deg.C) Solid
Storage Temperature Room Temperature (Recommended in a cool and dark place, <15°C)
CAS RN 75530-68-6
Reaxys Registry Number 3572609
PubChem Substance ID 135727167
Merck Index (14) 6545
MDL Number

MFCD00867065

Specifications
Appearance Light yellow to Amber to Dark green powder to crystal
Purity(HPLC) min. 98.0 area%
Purity(with Total Nitrogen) min. 95.0 %
Melting point 149.0 to 153.0 °C
NMR confirm to structure
Properties (reference)
Melting Point 151 °C
Solubility in water Insoluble
Solubility (soluble in) Methanol
Solubility (slightly sol. in) Ethanol
GHS
Pictogram Pictogram
Signal Word Warning
Hazard Statements H302 + H312 + H332 : Harmful if swallowed, in contact with skin or if inhaled.
H315 : Causes skin irritation.
H319 : Causes serious eye irritation.
Precautionary Statements P501 : Dispose of contents/ container to an approved waste disposal plant.
P261 : Avoid breathing dust/ fume/ gas/ mist/ vapors/ spray.
P270 : Do not eat, drink or smoke when using this product.
P271 : Use only outdoors or in a well-ventilated area.
P264 : Wash skin thoroughly after handling.
P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection.
P337 + P313 : If eye irritation persists: Get medical advice/ attention.
P305 + P351 + P338 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P362 + P364 : Take off contaminated clothing and wash it before reuse.
P332 + P313 : If skin irritation occurs: Get medical advice/ attention.
P301 + P312 + P330 : IF SWALLOWED: Call a POISON CENTER/doctor if you feel unwell. Rinse mouth.
P302 + P352 + P312 : IF ON SKIN: Wash with plenty of water.Call a POISON CENTER/doctor if you feel unwell.
P304 + P340 + P312 : IF INHALED: Remove person to fresh air and keep comfortable for breathing. Call a POISON CENTER/doctor if you feel unwell.
Related Laws:
RTECS# US7968300
Transport Information:
Application
長時間作動型のジヒドロピリジン系L型Ca2+チャンネル受容体アンタゴニスト,ニルバジピン

Nilvadipine is a dihydropyridine-derivative L-type Ca2+ channel receptor antagonist which relaxes arterial smooth muscle with high vascular selectivity and without changing serum calcium concentrations. This leads to prolonged vascular relaxation and lowering of blood pressure. In comparison with nifedipine [N0528], nilvadipine have a longer duration of action and a greater vasodilatory effect. Nilvadipine is mainly metabolized by CYP3A4 in the liver. Nilvadipine is a poorly water soluble agent, and its solid dispersions have been developed to the solubility. (The product is for research purpose only.)

References


PubMed Literature


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