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CAS RN: 25137-01-3 | Product Number: N0655
Ethyl (R)-(-)-3-Piperidinecarboxylate
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Purity: >98.0%(GC)
Synonyms:
- Ethyl (R)-(-)-Nipecotate
- (R)-(-)-Nipecotic Acid Ethyl Ester
- (R)-(-)-3-Piperidinecarboxylic Acid Ethyl Ester
Product Documents:
| Size | Unit Price | Hyderabad | Japan* | Quantity |
|---|---|---|---|---|
| 5G |
₹10,240.00
|
5 | 25 |
|
| 25G |
₹28,240.00
|
2 | 9 |
|
*Upon orders receipt, Hyderabad stocks will be dispatched on the same day.
*Items available in Japan warehouse will be dispatched in 10-12 working days.
*INR price is exclusive of domestic taxes applicable.
*TCI frequently reviews storage conditions to optimize them. Please note that the latest information on the storage temperature for the products is described on our website.
| Product Number | N0655 |
| Purity / Analysis Method | >98.0%(GC) |
| Molecular Formula / Molecular Weight | C__8H__1__5NO__2 = 157.21 |
| Physical State (20 deg.C) | Liquid |
| Storage Temperature | Refrigerated (0-10°C) |
| Store Under Inert Gas | Store under inert gas |
| Condition to Avoid | Air Sensitive,Moisture Sensitive,Heat Sensitive |
| CAS RN | 25137-01-3 |
| Reaxys Registry Number | 81695 |
| PubChem Substance ID | 87573967 |
| MDL Number | MFCD03093637 |
Specifications
| Appearance | Colorless to Almost colorless clear liquid |
| Purity(GC) | min. 98.0 % |
| Specific rotation [a]20/D | -1.0 to -2.0 deg(neat) |
| NMR | confirm to structure |
Properties (reference)
| Boiling Point | 110 °C/20 mmHg |
| Flash point | 90 °C |
| Specific Gravity (20/20) | 1.02 |
| Specific Rotation | -1.5° (neat) |
| Refractive Index | 1.46 |
GHS
| Pictogram |
|
| Signal Word | Warning |
| Hazard Statements | H315 : Causes skin irritation. H319 : Causes serious eye irritation. H227 : Combustible liquid. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P210 : Keep away from heat/sparks/open flames/hot surfaces. No smoking. P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ eye protection/ face protection. P302 + P352 : IF ON SKIN: Wash with plenty of water. P370 + P378 : In case of fire: Use dry sand, dry chemical or alcohol-resistant foam to extinguish. P337 + P313 : If eye irritation persists: Get medical advice/ attention. P305 + P351 + P338 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P362 + P364 : Take off contaminated clothing and wash it before reuse. P332 + P313 : If skin irritation occurs: Get medical advice/ attention. P403 + P235 : Store in a well-ventilated place. Keep cool. |
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Application
GABA再取り込み阻害剤 (R)-(-)-ニペコチン酸のプロドラッグ，(R)-(-)-ニペコチン酸エチル
Ethyl (R)-(-)-nipecotate is a prodrug of (R)-(-)-nipecotic acid [N0654] which is a γ-aminobutyric acid (GABA) reuptake inhibitor.1) In addition, some derivatives of ethyl (R)-(-)-nipecotate have been synthesized and evaluated for their bioactivity.2-4)
References
- 1)Influence of inhibitors of the high affinity GABA uptake on seizure thresholds in mice
- 2)Orally active and potent inhibitors of γ-aminobutyric acid uptake
- 3)The synthesis of novel GABA uptake inhibitors. 1. Elucidation of the structure-activity studies leading to the choice of (R)-1-[4,4-bis(3-methyl-2-thienyl)-3-butenyl]-3-piperidinecarboxylic acid (Tiagabine) as an anticonvulsant drug candidate
- 4)Design, Synthesis and Evaluation of Substituted Triarylnipecotic Acid Derivatives as GABA Uptake Inhibitors: Identification of a Ligand with Moderate Affinity and Selectivity for the Cloned Human GABA Transporter GAT-3
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