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CAS RN: 20244-86-4 | Product Number: M3465
7-Methylguanosine
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Purity: >85.0%(HPLC)(qNMR)
Synonyms:
- 2-Amino-6,9-dihydro-7-methyl-6-oxo-9-β-D-ribofuranosyl-1H-purinium
- 2-Amino-9-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]-7-methyl-6-oxo-6,9-dihydro-3H-purin-7-ium
Product Documents:
| Size | Unit Price | Hyderabad | Japan* | Quantity |
|---|---|---|---|---|
| 200MG |
₹7,400.00
|
1 | 13 |
|
| 1G |
₹23,200.00
|
1 | 16 |
|
*Upon orders receipt, Hyderabad stocks will be dispatched on the same day.
*Items available in Japan warehouse will be dispatched in 10-12 working days.
*INR price is exclusive of domestic taxes applicable.
*TCI frequently reviews storage conditions to optimize them. Please note that the latest information on the storage temperature for the products is described on our website.
| Product Number | M3465 |
| Purity / Analysis Method | >85.0%(HPLC)(qNMR) |
| Molecular Formula / Molecular Weight | C__1__1H__1__5N__5O__5 = 297.27 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Refrigerated (0-10°C) |
| Store Under Inert Gas | Store under inert gas |
| Condition to Avoid | Air Sensitive,Heat Sensitive |
| Packaging and Container | 1G-Glass Bottle with Plastic Insert (View image), 200MG-Glass Bottle with Plastic Insert (View image) |
| CAS RN | 20244-86-4 |
| Reaxys Registry Number | 3631436 |
| MDL Number | MFCD16661197 |
Specifications
| Appearance | White to Light yellow powder to crystal |
| Purity(HPLC) | min. 85.0 area% |
| Purity(qNMR) | min. 85.0 % |
| Water | max. 11.0 % |
| NMR | confirm to structure |
Properties (reference)
GHS
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Transport Information:
Application
RNA aptamer research
Reference
- In vitro selection of a 7-methyl-guanosine binding RNA that inhibits translation of capped mRNA molecules
Application
7-Methylguanosine (m7G): The 5' Terminal Cap Structure Present on Eukaryotic mRNA
7-Methylguanosine (m7G) is a purine base modified by the addition of a methyl group and closely resembles the 5' terminal cap structure present on eukaryotic mRNA. The 7-methylguanosine “cap’ is required for the translation of the majority of mRNAs, and it has also been reported to stabilize mRNA against attack by exonucleases and to promote transcription, splicing, polyadenylation and nuclear export of mRNA.1-3) Therefore, efficient mRNA capping enzymatic processes have been studied utilizing 7-methylguanosine.4) In addition, 7-methylguanosine cannot be re-phosphorylated and reused for de novo synthesis, and so is excreted by cells and can be detected in serum and urine. Therefore, it has been used as a biomarker for some types of cancer.5,6) (The product is for research purpose only.)
References
- 1) What messenger RNA capping tells us about eukaryotic evolution (a review)
- 2) Viral and cellular mRNA capping: Past and prospects (a review)
- 3) Regulation of mRNA cap methylation (a review)
- 4) Enzymatic Assays to Explore Viral mRNA Capping Machinery (a review)
- 5) Development and validation of a rapid LC-MS/MS method for determination of methylated nucleosides and nucleobases in urine
- 6) Epigenetics: Roles and therapeutic implications of non-coding RNA modifications in human cancers (a review)
Articles/Brochures
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