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CAS RN: 101152-94-7 | Product Number: M2133
Milnacipran Hydrochloride
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Purity: >98.0%(T)(HPLC)
Synonyms:
- cis-2-(Aminomethyl)-N,N-diethyl-1-phenylcyclopropanecarboxamide Hydrochloride
Product Documents:
| Size | Unit Price | Hyderabad | Japan* | Quantity |
|---|---|---|---|---|
| 50MG |
₹3,200.00
|
Contact Us | 26 |
|
| 500MG |
₹8,800.00
|
1 | 22 |
|
*Upon orders receipt, Hyderabad stocks will be dispatched on the same day.
*Items available in Japan warehouse will be dispatched in 10-12 working days.
*INR price is exclusive of domestic taxes applicable.
*TCI frequently reviews storage conditions to optimize them. Please note that the latest information on the storage temperature for the products is described on our website.
| Product Number | M2133 |
| Purity / Analysis Method | >98.0%(T)(HPLC) |
| Molecular Formula / Molecular Weight | C__1__5H__2__2N__2O·HCl = 282.81 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Refrigerated (0-10°C) |
| Condition to Avoid | Heat Sensitive |
| Packaging and Container | 500MG-Glass Bottle with Plastic Insert (View image) |
| CAS RN | 101152-94-7 |
| Related CAS RN | 92623-85-3 |
| Reaxys Registry Number | 6078861 |
| PubChem Substance ID | 125307702 |
| Merck Index (14) | 6194 |
| MDL Number | MFCD00901293 |
Specifications
| Appearance | White to Light yellow powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Nonaqueous Titration) | min. 98.0 % |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 181 °C(dec.) |
| Solubility in water | Soluble |
GHS
| Pictogram |
|
| Signal Word | Danger |
| Hazard Statements | H301 : Toxic if swallowed. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P270 : Do not eat, drink or smoke when using this product. P264 : Wash skin thoroughly after handling. P301 + P310 + P330 : IF SWALLOWED: Immediately call a POISON CENTER/doctor. Rinse mouth. P405 : Store locked up. |
Related Laws:
| RTECS# | GZ1014010 |
Transport Information:
| UN Number | UN2811 |
| Class | 6.1 |
| Packing Group | III |
Application
Milnacipran hydrochloride: A Selective Serotonin Noradrenaline Reuptake Inhibitor (SNRI)
Milnacipran hydrochloride is a selective serotonin noradrenaline reuptake inhibitor (SNRI) which acts by inhibiting noradrenaline (norepinephrine) and serotonin (5-hydroxytrytamine; 5-HT) reuptake at presynaptic sites. Milnacipran has unique characteristics that distinguish it from the other SNRIs, venlafaxine [V0110] and duloxetine [D4223], such as inhibition of noradrenaline reuptake with approximately 3-fold higher potency in vitro than serotonin. Milnacipran has no significantt affinity for other neurotransmitter receptors, such as serotonergic, α- and β-adrenergic, muscarinic, histamine, dopamine, opioid, benzodiazepine, and γ-aminobutyric acid (GABA) receptors in vitro. Milnacipran does not inhibit the activity of human monoamine oxidases (MAO-A and MAO-B) or acetylcholinesterase. (The product is for research purpose only.)
References
- Selective serotonin/noradrenaline reuptake inhibitors (SNRIs). Pharmacology and therapeutic potential in the treatment of depressive disorders (a review)
- Neurochemical and behavioral characterization of Milnacipran, a serotonin and noradrenaline reuptake inhibitor in rats
- Milnacipran: a comparative analysis of human monoamine uptake and transporter binding affinity
- High-performance liquid chromatographic method to screen and quantitate seven selective serotonin reuptake inhibitors in human serum
- A stability indicating U-HPLC method for milnacipran in bulk drugs and pharmaceutical dosage forms
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