Published TCIMAIL newest issue No.197 | New tool "TCI SpectraViewer" | [TCIPracticalExample] Three-component Reaction Using... | Product Document Searching Made Easy by 2D Code!
Maximum quantity allowed is 999
Please select the quantity
CAS RN: 6112-76-1 | Product Number: M0063
6-Mercaptopurine Monohydrate
×
![]()
×
Purity: >98.0%(T)(HPLC)
Synonyms:
Product Documents:
| Size | Unit Price | Hyderabad | Japan* | Quantity |
|---|---|---|---|---|
| 1G |
₹2,400.00
|
1 | 3 |
|
| 5G |
₹5,490.00
|
4 | ≥60 |
|
*Upon orders receipt, Hyderabad stocks will be dispatched on the same day.
*Items available in Japan warehouse will be dispatched in 10-12 working days.
*INR price is exclusive of domestic taxes applicable.
*TCI frequently reviews storage conditions to optimize them. Please note that the latest information on the storage temperature for the products is described on our website.
| Product Number | M0063 |
| Purity / Analysis Method | >98.0%(T)(HPLC) |
| Molecular Formula / Molecular Weight | C__5H__4N__4S·H__2O = 170.20 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Room Temperature (Recommended in a cool and dark place, <15°C) |
| Packaging and Container | 1G-Glass Bottle with Plastic Insert (View image) |
| CAS RN | 6112-76-1 |
| Related CAS RN | 50-44-2 |
| Reaxys Registry Number | 608605 |
| PubChem Substance ID | 87572176 |
| Merck Index (14) | 5871 |
| MDL Number | MFCD03854445 |
Specifications
| Appearance | Light yellow to Yellow powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Neutralization titration) | min. 98.0 % |
| Water | 9.9 to 11.5 % |
Properties (reference)
GHS
| Pictogram |
|
| Signal Word | Warning |
| Hazard Statements | H302 : Harmful if swallowed. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P270 : Do not eat, drink or smoke when using this product. P264 : Wash skin thoroughly after handling. P301 + P312 + P330 : IF SWALLOWED: Call a POISON CENTER/doctor if you feel unwell. Rinse mouth. |
Related Laws:
| RTECS# | UP0400000 |
Transport Information:
Application
6-Mercaptopurine: An Inhibitor of Purine Ribonucleotides and DNA/RNA Synthesis
6-Mercaptopurine (6-MP) is the first effective agent for leukemia, developed by Elion and Hitchings in 1950s. They shared the Nobel Prize in 1988. In cell, 6-MP is converted to 6-thioinosine monophosphate (TIMP), catalyzed by hypoxanthine guanine phosphoribosyltransferase (HPRT). TIMP inhibits conversion of inosinic acid to adenylosuccinic acid and xanthylic acid, subsequently leading to inhibition of purine ribonucleotides and DNA/RNA synthesis. Azathioprine [A2069] is a prodrug of 6-MP, and both are commonly used as an immunosuppressant for treatment of Crohn’s and inflammatory bowel disease. (The product is for research purpose only.)
References
- Historical background of 6-mercaptopurine
- Human liver thiopurine methyltransferase pharmacogenetics: biochemical properties, liver-erythrocyte correlation and presence of isozymes
- Differing contribution of thiopurine methyltransferase to mercaptopurine versus thioguanine effects in human leukemic cells
- CD28-dependent Rac1 activation is the molecular target of azathioprine in primary human CD4+ T lymphocytes
- High-performance liquid chromatographic assay of the methyl and nucleotide metabolites of 6-mercaptopurine: quantitation of red blood cell 6-thioguanine nucleotide, 6-thioinosinic acid and 6-methylmercaptopurine metabolites in a single sample
PubMed Literature
Articles/Brochures
TCIMAIL
Product Documents (Note: Some products will not have analytical charts available.)
Safety Data Sheet (SDS)
Please select Language.
The requested SDS is not available.
Please Contact Us for more information.
Specifications
C of A & Other Certificates
Please enter Lot Number
Incorrect Lot Number. Please input only the 4-5 alphanumeric characters before the hyphen.
Sample C of A
This is a sample C of A and may not represent a recently manufactured lot of the product.
A sample C of A for this product is not available at this time.
Analytical Charts
Please enter Lot Number
Incorrect Lot Number. Please input only the 4-5 alphanumeric characters before the hyphen.
The requested analytical chart is not available. Sorry for the inconvenience.