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CAS RN: 142273-20-9 | Product Number: K0052
Kenpaullone
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Purity: >97.0%(HPLC)
Synonyms:
- 9-Bromo-7,12-dihydroindolo[3,2-d][1]benzazepin-6(5H)-one
Product Documents:
| Size | Unit Price | Hyderabad | Japan* | Quantity |
|---|---|---|---|---|
| 10MG |
₹8,800.00
|
Contact Us | 10 |
|
| 50MG |
₹19,500.00
|
1 | 19 |
|
*Upon orders receipt, Hyderabad stocks will be dispatched on the same day.
*Items available in Japan warehouse will be dispatched in 10-12 working days.
*INR price is exclusive of domestic taxes applicable.
*TCI frequently reviews storage conditions to optimize them. Please note that the latest information on the storage temperature for the products is described on our website.
| Product Number | K0052 |
| Purity / Analysis Method | >97.0%(HPLC) |
| Molecular Formula / Molecular Weight | C__1__6H__1__1BrN__2O = 327.18 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Frozen (<0°C) |
| Store Under Inert Gas | Store under inert gas |
| Condition to Avoid | Air Sensitive,Heat Sensitive |
| CAS RN | 142273-20-9 |
| Reaxys Registry Number | 5346108 |
| PubChem Substance ID | 253661159 |
| MDL Number | MFCD02683595 |
Specifications
| Appearance | Light yellow to Brown powder to crystal |
| Purity(HPLC) | min. 97.0 area% |
| Elemental analysis(Nitrogen) | 8.00 to 9.00 % |
| NMR | confirm to structure |
Properties (reference)
GHS
| Pictogram |
|
| Signal Word | Warning |
| Hazard Statements | H315 : Causes skin irritation. H319 : Causes serious eye irritation. |
| Precautionary Statements | P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ eye protection/ face protection. P302 + P352 : IF ON SKIN: Wash with plenty of water. P337 + P313 : If eye irritation persists: Get medical advice/ attention. P305 + P351 + P338 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P362 + P364 : Take off contaminated clothing and wash it before reuse. P332 + P313 : If skin irritation occurs: Get medical advice/ attention. |
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Application
Kenpaullone: A Potent CDKs and GSK-3β Inhibitor
Kenpaullone is a potent ATP-competitive inhibitor of cyclin-dependent kinases (CDKs) and glycogen synthase kinase-3β (GSK-3β). In addition, kenpaullone can functionally replace Kruppel-like factor 4 (Klf4), which is a Yamanaka factors, in reprogramming induction.
References
- The specificities of protein kinase inhibitors: an update
- The selectivity of protein kinase inhibitors: a further update
- Comprehensive assay of kinase catalytic activity reveals features of kinase inhibitor selectivity
- Small molecule GSK-3 inhibitors increase neurogenesis of human neural progenitor cells
- Reprogramming of murine fibroblasts to induced pluripotent stem cells with chemical complementation of Klf4
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Specifications
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