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CAS RN: 53179-09-2 | Product Number: I1049
Sisomicin Sulfate
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Purity: >98.0%(HPLC)
Synonyms:
Product Documents:
| Size | Unit Price | Hyderabad | Japan* | Quantity |
|---|---|---|---|---|
| 250MG |
₹3,400.00
|
Contact Us | Contact Us |
|
| 1G |
₹9,600.00
|
Contact Us | Contact Us |
|
*Upon orders receipt, Hyderabad stocks will be dispatched on the same day.
*Items available in Japan warehouse will be dispatched in 10-12 working days.
*INR price is exclusive of domestic taxes applicable.
*TCI frequently reviews storage conditions to optimize them. Please note that the latest information on the storage temperature for the products is described on our website.
| Product Number | I1049 |
| Purity / Analysis Method | >98.0%(HPLC) |
| Molecular Formula / Molecular Weight | C__1__9H__3__7N__5O__7·2^^1/__2H__2SO__4 = 692.71 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Refrigerated (0-10°C) |
| Store Under Inert Gas | Store under inert gas |
| Condition to Avoid | Air Sensitive,Heat Sensitive |
| Packaging and Container | 1G-Glass Bottle with Plastic Insert (View image), 250MG-Glass Bottle with Plastic Insert (View image) |
| CAS RN | 53179-09-2 |
| Related CAS RN | 32385-11-8 |
| Reaxys Registry Number | 5709343 |
| PubChem Substance ID | 354335157 |
| Merck Index (14) | 8550 |
| MDL Number | MFCD00058308 |
Specifications
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Specific rotation [a]20/D | +98.0 to +104.0 deg(C=1, H2O) |
Properties (reference)
| Melting Point | 73 °C |
| Boiling Point | 155 °C |
| Specific Rotation | 100° (C=1,H2O) |
GHS
| Pictogram |
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| Signal Word | Danger |
| Hazard Statements | H360 : May damage fertility or the unborn child. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P202 : Do not handle until all safety precautions have been read and understood. P201 : Obtain special instructions before use. P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection. P308 + P313 : IF exposed or concerned: Get medical advice/ attention. P405 : Store locked up. |
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Application
Sisomicin Sulfate: An Aminoglycoside Antibiotic that is Effective against Pseudomonas aeruginosa
Sisomicin sulfate is a naturally occurring aminoglycoside antibiotic produced by Micromonospora inyoensis. Sisomicin is bactericidal in action against a wide range of Gram-negative and Gram-positive bacteria, including Klebsiella species, Escherichia coli, Pseudomonas aeruginosa, Enterobacter species, and Proteus species. Sisomicin is closely related structurally to gentamicin [G0383], but in vitro studies have shown it to have superior activity to gentamicin against Pseudomonas aeruginosa. Sisomicin, like that of the other aminoglycoside antibiotics, binds the 30s ribosomal subunit, causing misreading of the mRNA sequence and inhibition of transcription. Consequently, bacterial protein synthesis is inhibited. (The product is for research purpose only.)
References
- Activity of five aminoglycoside antibiotics in vitro against gram-negative bacilli and Staphylococcus aureus
- Sisomicin, netilmicin and dibekacin: a review of their antibacterial activity and therapeutic use
- Sisomicin: an aminoglycoside antibiotic that is highly effective against Pseudomonas (a review)
- High-performance liquid chromatographic analysis of aminoglycoside antibiotics
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