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CAS RN: 14047-28-0 | Product Number: H1291
(R)-9-(2-Hydroxypropyl)adenine
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Purity: >98.0%(T)(HPLC)
Synonyms:
- (R)-6-Amino-9-(2-hydroxypropyl)purine
Product Documents:
| Size | Unit Price | Hyderabad | Japan* | Quantity |
|---|---|---|---|---|
| 1G |
₹4,240.00
|
Contact Us | ≥100 |
|
| 5G |
₹16,960.00
|
Contact Us | 1 |
|
*Upon orders receipt, Hyderabad stocks will be dispatched on the same day.
*Items available in Japan warehouse will be dispatched in 10-12 working days.
*INR price is exclusive of domestic taxes applicable.
*TCI frequently reviews storage conditions to optimize them. Please note that the latest information on the storage temperature for the products is described on our website.
| Product Number | H1291 |
| Purity / Analysis Method | >98.0%(T)(HPLC) |
| Molecular Formula / Molecular Weight | C__8H__1__1N__5O = 193.21 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Room Temperature (Recommended in a cool and dark place, <15°C) |
| Store Under Inert Gas | Store under inert gas |
| Condition to Avoid | Moisture Sensitive |
| CAS RN | 14047-28-0 |
| PubChem Substance ID | 253662428 |
| MDL Number | MFCD07369451 |
Specifications
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Nonaqueous Titration) | min. 98.0 % |
| Melting point | 198.0 to 202.0 °C |
| Specific rotation [a]20/D | -41.0 to -46.0 deg(C=1,EtOH) |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 200 °C |
| Specific Rotation | -42° (C=1,EtOH) |
| Solubility (soluble in) | Dimethylformamide |
GHS
| Pictogram |
|
| Signal Word | Warning |
| Hazard Statements | H315 : Causes skin irritation. H319 : Causes serious eye irritation. |
| Precautionary Statements | P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ eye protection/ face protection. P302 + P352 : IF ON SKIN: Wash with plenty of water. P337 + P313 : If eye irritation persists: Get medical advice/ attention. P305 + P351 + P338 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P362 + P364 : Take off contaminated clothing and wash it before reuse. P332 + P313 : If skin irritation occurs: Get medical advice/ attention. |
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Application
An Intermediate for the Synthesis of Tenofovir, a Nucleotide Reverse Transcriptase Inhibitor
This compound is an intermediate for the synthesis of tenofovir [T3006], a nucleotide reverse transcriptase (RT) inhibitor and antiretroviral agent.
References
- Synthesis of enantiomeric N-(2-phosphonomethoxypropyl) derivatives of purine and pyrimidine bases. I. The stepwiseapproach
- Practical synthesis of the anti-HIV drug, PMPA
- Process Improvements for the Manufacture of Tenofovir Disoproxil Fumarate at Commercial Scale
- The synthesis of tenofovir and its analogues via asymmetric transfer hydrogenation
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