Haloperidol: A Dopamine Receptor (D2) and a Serotonin Receptor (5-HT2) Antagonist
Haloperidol is a butyrophenone series of neurotransmitter agent. The precise mechanism of action has not been clearly established, but it has been shown to be a dopamine receptor (D
2) and a serotonin receptor (5-HT
2) antagonist. Therefore, haloperidol is classified as a neuroleptic. Haloperidol is metabolized by several routes including the cytochrome P450 enzyme system (particularly CYP3A4 or CYP2D6). Hence, haloperidol inhibits the metabolism of tricyclic antidepressants such as doxepin hydrochloride [
D4626] and imipramine hydrochloride [
I0971] , increasing the blood levels of these agents. Haloperidol has no anti-histaminergic or anticholinergic activity. Haloperidol is almost insoluble in water, but is soluble in most organic solvents. (The product is for research purpose only.)