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CAS RN: 180200-66-2 | Product Number: G0627
Gatifloxacin Sesquihydrate
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Purity: >95.0%(T)(HPLC)
Synonyms:
- 1-Cyclopropyl-6-fluoro-8-methoxy-7-(3-methylpiperazin-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic Acid Sesquihydrate
Product Documents:
| Size | Unit Price | Hyderabad | Japan* | Quantity |
|---|---|---|---|---|
| 5G |
₹3,500.00
|
3 | 17 |
|
| 25G |
₹13,400.00
|
Contact Us | 31 |
|
*Upon orders receipt, Hyderabad stocks will be dispatched on the same day.
*Items available in Japan warehouse will be dispatched in 10-12 working days.
*INR price is exclusive of domestic taxes applicable.
*TCI frequently reviews storage conditions to optimize them. Please note that the latest information on the storage temperature for the products is described on our website.
| Product Number | G0627 |
| Purity / Analysis Method | >95.0%(T)(HPLC) |
| Molecular Formula / Molecular Weight | C__1__9H__2__2FN__3O__4·1^^1/__2H__2O = 402.42 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Refrigerated (0-10°C) |
| Store Under Inert Gas | Store under inert gas |
| Condition to Avoid | Air Sensitive,Hygroscopic,Heat Sensitive |
| CAS RN | 180200-66-2 |
| Reaxys Registry Number | 14390028 |
| MDL Number | MFCD22373645 |
Specifications
| Appearance | White to Light yellow powder to crystal |
| Purity(HPLC) | min. 95.0 area% |
| Purity(Neutralization titration) | min. 95.0 % |
| Melting point | 179.0 to 183.0 °C |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 181 °C |
GHS
Related Laws:
| RTECS# | VB1983650 |
Transport Information:
Application
Gatifloxacin: An 8-Methoxy Fluoroquinolone Antibacterial Agent with a Broad Antibacterial Spectrum
Gatifloxacin (AM-1155) is an 8-methoxy fluoroquinolone antibacterial agent with a 3-methylpiperazinyl substituent at C7. Fluoroquinolone fungicidal antibacterial agents are inhibitors of bacterial DNA gyrase and topoisomerase IV.1,2) DNA gyrase is an essential enzyme involved in the replication, transcription and repair of bacterial DNA. Topoisomerase IV is an enzyme known to play a key role in the division of chromosomal DNA during bacterial cell division. As just described, the mechanism of action of fluoroquinolones is different from that of other antibiotics. Therefore, there is no cross-resistance between fluoroquinolones and the other classes of antibiotics. In particular, gatifloxacin has a broader spectrum of antibacterial activity than the older fluoroquinolones and shows good activity against many Gram-positive and Gram-negative bacteria, atypical organisms and some anaerobes.3) In addition, gatifloxacin has higher selectivity for bacterial type II topoisomerases.4) (The product is for research purpose only.)
References
- 1) In vitro and in vivo antibacterial activities of AM-1155, a new 6-fluoro-8-methoxy quinoline
- 2) Quinolone-mediated bacterial death (a review)
- 3) Comparison of the antibacterial activities of the quinolones Bay 12-8039, gatifloxacin (AM 1155), trovafloxacin, clinafloxacin, levofloxacin and ciprofloxacin
- 4) Inhibitory Activities of Gatifloxacin (AM-1155), a Newly Developed Fluoroquinolone, against Bacterial and Mammalian Type II Topoisomerases
- 5) Separation of levofloxacin, ciprofloxacin, gatifloxacin, moxifloxacin, trovafloxacin and cinoxacin by high-performance liquid chromatography: application to levofloxacin determination in human plasma
- 6) Gatifloxacin (a review)
Product Documents (Note: Some products will not have analytical charts available.)
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Specifications
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