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CAS RN: 220904-83-6 | Product Number: G0609

GW-5074


Purity: >95.0%(HPLC)
Synonyms:
  • 3-(3,5-Dibromo-4-hydroxybenzylidene)-5-iodoindolin-2-one
Product Documents:
100MG
₹19,600.00
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Product Number G0609
Purity / Analysis Method >95.0%(HPLC)
Molecular Formula / Molecular Weight C__1__5H__8Br__2INO__2 = 520.95 
Physical State (20 deg.C) Solid
Storage Temperature Room Temperature (Recommended in a cool and dark place, <15°C)
Store Under Inert Gas Store under inert gas
Condition to Avoid Light Sensitive,Air Sensitive
CAS RN 220904-83-6
Reaxys Registry Number 8641129
MDL Number

MFCD09971042

Specifications
Appearance White to Yellow powder to crystal
Purity(HPLC) min. 95.0 %(total of isomers)
NMR confirm to structure
Properties (reference)
Melting Point 262 °C
GHS
Related Laws:
RTECS# NM3249100
Transport Information:
Application
GW5074: An Inhibitor of Raf-1 and LRRK2

GW5074 has been used as a potent and selective inhibitor of Raf-1 (c-Raf) which is a serine/threonine protein kinase that signals from Ras to the MAPK/ERK signaling pathway.1,2) Recently, it has been reported that GW5974 is also an inhibitor of the autophosphorylation of leucine-rich repeat kinase 2 (LRRK2), which is a large, multidomain protein containing two catalytic domains: a Ras of complex proteins (Roc) G-domain and a kinase domain.3-6) GW5074 is of interest for studying Parkinson's disease (PD), because mutations in the gene encoding Parkinson’s protein LRRK2 indicate LRRK2 as promising therapeutic target for the treatment of PD. (The product is for research purpose only.)

References


Product Documents (Note: Some products will not have analytical charts available.)
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Specifications
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Other Documents

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