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Published TCIMAIL newest issue No.200 | Product Document Searching Made Easy by 2D Code! | [Product Highlights] Cell Culture-Ready Antibiotic...

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CAS RN: 259793-96-9 | Product Number: F1296

Favipiravir

Purity: >98.0%(HPLC)

Synonyms:

T-705
6-Fluoro-3-hydroxy-2-pyrazinecarboxamide
6-Fluoro-3-hydroxypyrazine-2-carboxamide

Product Documents:

Size	Unit Price	Hyderabad	Japan*	Quantity
25MG	₹7,200.00	2	26
100MG	₹9,500.00	3	≥40

*Upon orders receipt, Hyderabad stocks will be dispatched on the same day.
*Items available in Japan warehouse will be dispatched in 10-12 working days.
*INR price is exclusive of domestic taxes applicable.
*TCI frequently reviews storage conditions to optimize them. Please note that the latest information on the storage temperature for the products is described on our website.

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Supplemental Product Information:

This product is a sample for RUO (research use only). Do not use this product for any purpose other than testing and research.

General Information plus

Specifications & Properties plus

Specifications

Appearance	White to Almost white powder to crystal
Purity(HPLC)	min. 98.0 area%
Melting point	190.0 to 194.0 °C

Properties (reference)

Melting Point	192 °C
Solubility (slightly sol. in)	Methanol

Safety & Regulations plus

GHS

Pictogram
Signal Word	Warning
Hazard Statements	H361 : Suspected of damaging fertility or the unborn child.
Precautionary Statements	P501 : Dispose of contents/ container to an approved waste disposal plant. P202 : Do not handle until all safety precautions have been read and understood. P201 : Obtain special instructions before use. P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection. P308 + P313 : IF exposed or concerned: Get medical advice/ attention. P405 : Store locked up.

Related Laws:

RTECS#

UQ2281100

Transport Information:

Applications & Literature plus

Application

Favipiravir: A Potent and Selective Viral RNA Polymerase Inhibitor

Favipiravir (T-705) is an antiviral agent developed by Shiraki, et al. It has been found to have potent and selective inhibitory activity against RNA-dependent RNA polymerase of RNA viruses, such as influenza A, B, and C viruses.^1-4) Its ribose-5’-triphosphate is the active metabolite, and it is recognized by virus RNA polymerase as a substrate competing with guanosine 5'-triphosphate (GTP), giving inhibition of viral RNA synthesis. On the other hand, it has been pointed out that favipiravir has a risk for teratogenicity and embryotoxicity.⁴⁾ Recently, favipiravir has been also reported to show potential anti Ebola virus and coronavirus (SARS-CoV-2) activities.^4-7) For your reference, T-1105 [H1485], an antiviral agent, is an analog replacing the 6-fluoro atom to hydrogen. (The product is for research purpose only.)

References

1) In vitro and in vivo activities of anti-influenza virus compound T-705
- Y. Furuta, K. Takahashi, Y. Fukuda, M. Kuno, T. Kamiyama, K. Kozaki, N. Nomura, H. Egawa, S. Minami, Y. Watanabe, H. Narita, K. Shiraki, Antimicrob. Agents Chemother. 2002, 46, 977.
2) Mechanism of action of T-705 against influenza virus
- Y. Furuta, K. Takahashi, M. Kuno-Maekawa, H. Sangawa, S. Uehara, K. Kozaki, N. Nomura, H. Egawa, K. Shiraki, Antimicrob. Agents Chemother. 2005, 49, 981.
3) Favipiravir (T-705), a novel viral RNA polymerase inhibitor (a review)
- Y. Furuta, B. B. Gowen, K. Takahashi, K. Shiraki, D. F. Smee, D. L. Barnard, Antiviral Res. 2013, 100, 446.
4) Favipiravir (T-705), a broad spectrum inhibitor of viral RNA polymerase (a review)
- Y. Furuta, T. Komeno, T. Nakamura, Proc. Jpn. Acad., Ser. B 2017, 93, 449.
5) Successful treatment of advanced Ebola virus infection with T-705 (favipiravir) in a small animal model
- L. Oestereich, A. Lüdtke, S. Wurr, T. Rieger, C. Muñoz-Fontela, S. Günther, Antiviral Res. 2014, 105, 17.
6) Discovering drugs to treat coronavirus disease 2019 (COVID-19).
- L. Dong, S. Hu, J. Gao, Drug Discoveries Ther. 2020, 14, 58.
7) Remdesivir, lopinavir, emetine, and homoharringtonine inhibit SARS-CoV-2 replication in vitro
- Ka-Tim Choy, A. Y.-L. Wong, P. Kaewpreedee, S. F. Sia, D. Chen, K. Pui, Y. Hui, D. K. W. Chu, M. C. W. Chan, P. P.-H. Cheung, Xuhui Huang, M. Peiris, H.-L. Yen, Antiviral Res. 2020, 178, 104786.

Documents

Antiviral Agents Targeting RNA-Dependent RNA Polymerase (RdRp)

Product Articles

[Featured Products] RNA-dependent RNA Polymerase Inhibitors

Product Documents (Note: Some products will not have analytical charts available.)

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Product Categories

Chemistry

Building Blocks

Heterocyclic Building Blocks

Non-Halogenated Heterocyclic Building Blocks

Pyrazines [Non-Halogenated Heterocyclic Building Blocks]

Chemicals by Class

6-Membered Heterocyclic Compounds [Chemical Structural Class]

Pyrazines [Chemical Structural Class]

Chloropyrazines, etc. [Chemical Structural Class]

Life Science

Chemistry

Building Blocks

Heterocyclic Building Blocks

Non-Halogenated Heterocyclic Building Blocks

Pyrazines [Non-Halogenated Heterocyclic Building Blocks]

Chemicals by Class

6-Membered Heterocyclic Compounds [Chemical Structural Class]

Pyrazines [Chemical Structural Class]

Chloropyrazines, etc. [Chemical Structural Class]

Product Number	F1296
Purity / Analysis Method	>98.0%(HPLC)
Molecular Formula / Molecular Weight	C__5H__4FN__3O__2 = 157.10
Physical State (20 deg.C)	Solid
Storage Temperature	Refrigerated (0-10°C)
Store Under Inert Gas	Store under inert gas
Condition to Avoid	Air Sensitive,Heat Sensitive
Packaging and Container	100MG-Glass Bottle with Plastic Insert (View image), 25MG-Glass Bottle with Plastic Insert (View image)
CAS RN	259793-96-9
Reaxys Registry Number	9697246
MDL Number	MFCD12032148

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CAS RN: 259793-96-9 | Product Number: F1296