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CAS RN: 152121-47-6 | Product Number: F0864
SB 203580
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Purity: >98.0%(HPLC)
Synonyms:
- 4-(4-Fluorophenyl)-2-(4-methylsulfinylphenyl)-5-(4-pyridyl)-1H-imidazole
Product Documents:
| Size | Unit Price | Hyderabad | Japan* | Quantity |
|---|---|---|---|---|
| 25MG |
₹6,500.00
|
Contact Us | 29 |
|
| 100MG |
₹14,800.00
|
Contact Us | 23 |
|
*Upon orders receipt, Hyderabad stocks will be dispatched on the same day.
*Items available in Japan warehouse will be dispatched in 10-12 working days.
*INR price is exclusive of domestic taxes applicable.
*TCI frequently reviews storage conditions to optimize them. Please note that the latest information on the storage temperature for the products is described on our website.
| Product Number | F0864 |
| Purity / Analysis Method | >98.0%(HPLC) |
| Molecular Formula / Molecular Weight | C__2__1H__1__6FN__3OS = 377.44 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Frozen (-20°C) |
| Condition to Avoid | Heat Sensitive |
| Packaging and Container | 25MG-Glass Bottle with Plastic Insert (View image) |
| CAS RN | 152121-47-6 |
| Reaxys Registry Number | 7599740 |
| PubChem Substance ID | 468591804 |
| MDL Number | MFCD00922198 |
Specifications
| Appearance | White to Orange to Green powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Melting point | 243.0 to 247.0 °C |
| Elemental analysis(Nitrogen) | 10.60 to 11.60 % |
Properties (reference)
| Melting Point | 245 °C |
GHS
Related Laws:
| RTECS# | UT3967600 |
Transport Information:
Application
SB 203580: A Cell-Permeable and Specific p38 MAPK Inhibitor
Mitogen-activated protein kinase (MAPK) mediate signal transduction from cell surface receptors to the nucleus. p38 MAPK, a subtype of MAPK, is activated responsive to stress stimuli, such as cytokines, ultraviolet irradiation, heat shock, and osmotic shock, and are involved in cell differentiation, apoptosis and autophagy. SB 203580 is a cell-permeable p38 MAPK inhibitor that specifically blocks its kinase activity. Therefore, SB 203580 is widely used to elucidate the role of p38 MAPK in a wide array of biological systems.
References
- SB 203580 is a specific inhibitor of a MAP kinase homologue which is stimulated by cellular stresses and interleukin-1
- Pharmacological profile of SB 203580, a selective inhibitor of cytokine suppressive binding protein/p38 kinase, in animal models of arthritis, bone resorption, endotoxin shock and immune function
- p38 mitogen-activated protein kinase inhibitors--mechanisms and therapeutic potentials (a review)
- Roles of p38 MAPKs in invasion and metastasis (a review)
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