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CAS RN: 153439-40-8 | Product Number: F0698
Fexofenadine Hydrochloride
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Purity: >98.0%(T)(HPLC)
Synonyms:
Product Documents:
| Size | Unit Price | Hyderabad | Japan* | Quantity |
|---|---|---|---|---|
| 1G |
₹10,600.00
|
3 | ≥80 |
|
| 5G |
₹11,000.00
|
2 | 26 |
|
*Upon orders receipt, Hyderabad stocks will be dispatched on the same day.
*Items available in Japan warehouse will be dispatched in 10-12 working days.
*INR price is exclusive of domestic taxes applicable.
*TCI frequently reviews storage conditions to optimize them. Please note that the latest information on the storage temperature for the products is described on our website.
| Product Number | F0698 |
| Purity / Analysis Method | >98.0%(T)(HPLC) |
| Molecular Formula / Molecular Weight | C__3__2H__3__9NO__4·HCl = 538.13 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Frozen (<0°C) |
| Condition to Avoid | Heat Sensitive |
| Packaging and Container | 1G-Glass Bottle with Plastic Insert (View image) |
| CAS RN | 153439-40-8 |
| Related CAS RN | 138452-21-8&83799-24-0 |
| Reaxys Registry Number | 7900041 |
| PubChem Substance ID | 87561226 |
| Merck Index (14) | 4068 |
| MDL Number | MFCD00865710 |
Specifications
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Neutralization titration) | min. 98.0 % |
Properties (reference)
| Solubility (soluble in) | Methanol |
GHS
Related Laws:
Transport Information:
Application
Fexofenadine: A Second-Generation Selective Histamine H1 Receptor Antagonist
Fexofenadine is a second-generation selective histamine H1 receptor antagonist that does not cross the blood brain barrier. Fexofenadine competitively binds peripheral H1-receptors, thereby stabilizing an inactive conformation of the receptor. Consequently, usual allergic responses as a result of mast-cell degranulation followed by the release of multiple inflammatory mediators, such as interleukins, prostaglandins, and leukotriene precursors, are blocked. Grapefruit and other fruit juices have recently been shown to be potent inhibitors of a number of organic anion-transporting polypeptides (OATPs) in the gastrointestinal tract. Thus, these juices decrease the absorption of fexofenadine by inhibiting the activity of OATPs. For your reference, fexofenadine is the active metabolite of terfenadine [T3977]. (The product is for research purpose only.)
References
- Fexofenadine: a review of its use in the management of seasonal allergic rhinitis and chronic idiopathic urticarial
- Comparison of pharmacokinetics and metabolism of desloratadine, fexofenadine, levocetirizine and mizolastine in humans (a review)
- OATP and P-glycoprotein transporters mediate the cellular uptake and excretion of fexofenadine
- Fruit juices inhibit organic anion transporting polypeptide-mediated drug uptake to decrease the oral availability of fexofenadine
- Contribution of OATP (organic anion-transporting polypeptide) family transporters to the hepatic uptake of fexofenadine in humans
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