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CAS RN: 54863-37-5 | Product Number: D5955
Dapansutrile
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Purity: >98.0%(GC)
Synonyms:
- OLT 1177
- 3-(Methylsulfonyl)propanenitrile
- 3-(Methylsulfonyl)propionitrile
Product Documents:
| Size | Unit Price | Hyderabad | Japan* | Quantity |
|---|---|---|---|---|
| 100MG |
₹6,600.00
|
1 | 9 |
|
| 1G |
₹28,800.00
|
Contact Us | 15 |
|
*Upon orders receipt, Hyderabad stocks will be dispatched on the same day.
*Items available in Japan warehouse will be dispatched in 10-12 working days.
*INR price is exclusive of domestic taxes applicable.
*TCI frequently reviews storage conditions to optimize them. Please note that the latest information on the storage temperature for the products is described on our website.
| Product Number | D5955 |
| Purity / Analysis Method | >98.0%(GC) |
| Molecular Formula / Molecular Weight | C__4H__7NO__2S = 133.17 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Frozen (<0°C) |
| Store Under Inert Gas | Store under inert gas |
| Condition to Avoid | Air Sensitive,Heat Sensitive |
| Packaging and Container | 100MG-Glass Bottle with Plastic Insert (View image) |
| CAS RN | 54863-37-5 |
| Reaxys Registry Number | 1751247 |
| PubChem Substance ID | 468591664 |
| MDL Number | MFCD11934305 |
Specifications
| Appearance | White to Light yellow powder to crystal |
| Purity(GC) | min. 98.0 % |
| Melting point | 73.0 to 77.0 °C |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 75 °C |
GHS
| Pictogram |
|
| Signal Word | Warning |
| Hazard Statements | H302 + H312 + H332 : Harmful if swallowed, in contact with skin or if inhaled. H315 : Causes skin irritation. H319 : Causes serious eye irritation. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P261 : Avoid breathing dust/ fume/ gas/ mist/ vapors/ spray. P270 : Do not eat, drink or smoke when using this product. P271 : Use only outdoors or in a well-ventilated area. P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection. P337 + P313 : If eye irritation persists: Get medical advice/ attention. P305 + P351 + P338 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P362 + P364 : Take off contaminated clothing and wash it before reuse. P332 + P313 : If skin irritation occurs: Get medical advice/ attention. P301 + P312 + P330 : IF SWALLOWED: Call a POISON CENTER/doctor if you feel unwell. Rinse mouth. P302 + P352 + P312 : IF ON SKIN: Wash with plenty of water.Call a POISON CENTER/doctor if you feel unwell. P304 + P340 + P312 : IF INHALED: Remove person to fresh air and keep comfortable for breathing. Call a POISON CENTER/doctor if you feel unwell. |
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Application
Dapansutrile (OLT1177): An Orally Active NLRP3 inflammasome Inhibitor
Recently, it has been reported that the NLR family pyrin domain-containing protein 3 (NLRP3), a pattern recognition receptor, forms a complex called the NLRP3 inflammasome in response to irritant metabolites and pathogens and induces the production of pro-inflammatory cytokines, interleukin (IL)-1β and IL-18. The NLRP3 inflammasome has been implicated in a wide range of diseases, including Alzheimer’s disease, Prion diseases, type 2 diabetes, and some infectious diseases. Dapansutrile (OLT1177), a β-sulfonyl nitrile compound, is an orally active NLRP3 inflammasome inhibitor with anti-inflammatory activity. (The product is for research purpose only.)
References
- OLT1177, a β-sulfonyl nitrile compound, safe in humans, inhibits the NLRP3 inflammasome and reverses the metabolic cost of inflammation
- NLRP3 inflammasome inhibitor OLT1177 suppresses joint inflammation in murine models of acute arthritis
- The NLRP3 Inflammasome Inhibitor, OLT1177 (Dapansutrile), Reduces Infarct Size and Preserves Contractile Function After Ischemia Reperfusion Injury in the Mouse
- The NLRP3 inflammasome inhibitor OLT1177 rescues cognitive impairment in a mouse model of Alzheimer's disease
- Recent advances in the mechanisms of NLRP3 inflammasome activation and its inhibitors (a review)
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