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CAS RN: 150728-13-5 | Product Number: D4598
4,6-Dichloro-5-(2-methoxyphenoxy)-2,2'-bipyrimidine
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Purity: >98.0%(GC)(N)
Synonyms:
Product Documents:
| Size | Unit Price | Hyderabad | Japan* | Quantity |
|---|---|---|---|---|
| 1G |
₹5,840.00
|
4 | 8 |
|
| 5G |
₹19,200.00
|
4 | 7 |
|
*Upon orders receipt, Hyderabad stocks will be dispatched on the same day.
*Items available in Japan warehouse will be dispatched in 10-12 working days.
*INR price is exclusive of domestic taxes applicable.
*TCI frequently reviews storage conditions to optimize them. Please note that the latest information on the storage temperature for the products is described on our website.
| Product Number | D4598 |
| Purity / Analysis Method | >98.0%(GC)(N) |
| Molecular Formula / Molecular Weight | C__1__5H__1__0Cl__2N__4O__2 = 349.17 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Room Temperature (Recommended in a cool and dark place, <15°C) |
| CAS RN | 150728-13-5 |
| Reaxys Registry Number | 7775899 |
| PubChem Substance ID | 253660544 |
| MDL Number | MFCD03839838 |
Specifications
| Appearance | White to Light yellow powder to crystal |
| Purity(GC) | min. 98.0 % |
| Purity(with Total Nitrogen) | min. 98.0 % |
| Melting point | 157.0 to 161.0 °C |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 159 °C |
GHS
| Pictogram |
|
| Signal Word | Warning |
| Hazard Statements | H315 : Causes skin irritation. H319 : Causes serious eye irritation. |
| Precautionary Statements | P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ eye protection/ face protection. P302 + P352 : IF ON SKIN: Wash with plenty of water. P337 + P313 : If eye irritation persists: Get medical advice/ attention. P305 + P351 + P338 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P362 + P364 : Take off contaminated clothing and wash it before reuse. P332 + P313 : If skin irritation occurs: Get medical advice/ attention. |
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Application
A Synthetic Intermediate of Bosentan
This product has been used as a synthetic intermediate of bosentan [B5118], which is a dual endothelin receptor antagonist with affinity for both ETA and ETB receptors.
References
- Research and Development of a Second-Generation Process for Bosentan, an Endothelin Receptor Antagonist
- Facile One-Pot Process for Large-Scale Production of Highly Pure Bosentan Monohydrate, an Endothelin Receptor Antagonist
- Improved Procedure for the Preparation of Bosentan, an Endothelin Receptor Antagonist
- A New Efficient Synthetic Process for an Endothelin Receptor Antagonist, Bosentan Monohydrate
PubMed Literature
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Safety Data Sheet (SDS)
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