Published TCIMAIL newest issue No.197 | New tool "TCI SpectraViewer" | [TCIPracticalExample] Three-component Reaction Using... | Product Document Searching Made Easy by 2D Code!
Maximum quantity allowed is 999
Please select the quantity
CAS RN: 152-53-4 | Product Number: C3900
Cycloguanil Hydrochloride
×
![]()
×
Purity: >95.0%(T)(HPLC)
Synonyms:
- Chloroguanide Triazine Hydrochloride
- 1-(4-Chlorophenyl)-1,6-dihydro-6,6-dimethyl-1,3,5-triazine-2,4-diamine Hydrochloride
Product Documents:
| Size | Unit Price | Hyderabad | Japan* | Quantity |
|---|---|---|---|---|
| 100MG |
₹11,840.00
|
Contact Us | 22 |
|
*Upon orders receipt, Hyderabad stocks will be dispatched on the same day.
*Items available in Japan warehouse will be dispatched in 10-12 working days.
*INR price is exclusive of domestic taxes applicable.
*TCI frequently reviews storage conditions to optimize them. Please note that the latest information on the storage temperature for the products is described on our website.
| Product Number | C3900 |
| Purity / Analysis Method | >95.0%(T)(HPLC) |
| Molecular Formula / Molecular Weight | C__1__1H__1__4ClN__5·HCl = 288.18 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Frozen (-20°C) |
| Store Under Inert Gas | Store under inert gas |
| Condition to Avoid | Air Sensitive,Hygroscopic,Heat Sensitive |
| CAS RN | 152-53-4 |
| Reaxys Registry Number | 3751988 |
| MDL Number | MFCD00035308 |
Specifications
| Appearance | White to Light yellow powder to crystal |
| Purity(HPLC) | min. 95.0 area% |
| Purity(Precipitation Titration) | min. 95.0 % |
| Melting point | 209.0 to 213.0 °C |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 211 °C |
GHS
| Pictogram |
|
| Signal Word | Warning |
| Hazard Statements | H315 : Causes skin irritation. H319 : Causes serious eye irritation. |
| Precautionary Statements | P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ eye protection/ face protection. P302 + P352 : IF ON SKIN: Wash with plenty of water. P337 + P313 : If eye irritation persists: Get medical advice/ attention. P305 + P351 + P338 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P362 + P364 : Take off contaminated clothing and wash it before reuse. P332 + P313 : If skin irritation occurs: Get medical advice/ attention. |
Related Laws:
| RTECS# | GU2625000 |
Transport Information:
Application
Cycloguanil Hydrochloride: An Inhibitor of Dihydrofolate Reductase (DHFR)
Cycloguanil hydrochloride is an inhibitor of dihydrofolate reductase (DHFR).1-3) By blocking DHFR activity, cycloguanil prevents the production of tetrahydrofolic acid, an essential coenzyme involved in DNA and RNA synthesis. In addition, cycloguanil is an active metabolite of proguanil, produced by the P450 2C19 isoform. Cycloguanil hydrochloride is used as an antimalarial agent used in combination reagent with the other antimalarial atovaquone [A2545] against Plasmodium infections.4) (The product is for research purpose only.)
References
- 1) Amino acids in the dihydrofolate reductase-thymidylate synthase gene of Plasmodium falciparum involved in cycloguanil resistance differ from those involved in pyrimethamine resistance
- 2) Dihydrofolate reductase and antifolate resistance in malaria (a review)
- 3) Malarial (Plasmodium falciparum) dihydrofolate reductase-thymidylate synthase: structural basis for antifolate resistance and development of effective inhibitors (a review)
- 4) Interactions of atovaquone with other antimalarial drugs against Plasmodium falciparum in vitro
Product Documents (Note: Some products will not have analytical charts available.)
Safety Data Sheet (SDS)
Please select Language.
The requested SDS is not available.
Please Contact Us for more information.
Specifications
C of A & Other Certificates
Please enter Lot Number
Incorrect Lot Number. Please input only the 4-5 alphanumeric characters before the hyphen.
Sample C of A
This is a sample C of A and may not represent a recently manufactured lot of the product.
A sample C of A for this product is not available at this time.
Analytical Charts
Please enter Lot Number
Incorrect Lot Number. Please input only the 4-5 alphanumeric characters before the hyphen.
The requested analytical chart is not available. Sorry for the inconvenience.