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Published TCIMAIL newest issue No.200 | Product Document Searching Made Easy by 2D Code! | [Product Highlights] Phthalimide-Containing Acrylic Monomers...

Users can now ask questions to the AI chatbot by clicking the chatbot icon in the bottom-right corner of the website.

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CAS RN: 29342-05-0 | Product Number: C3483

Ciclopirox

Purity: >98.0%(T)(HPLC)

Synonyms:

6-Cyclohexyl-1-hydroxy-4-methyl-2(1H)-pyridinone
6-Cyclohexyl-1-hydroxy-4-methylpyridin-2(1H)-one

Product Documents:

Size	Unit Price	Hyderabad	Japan*	Quantity
1G	₹2,300.00	6	10
5G	₹6,700.00	2	≥40

*Upon orders receipt, Hyderabad stocks will be dispatched on the same day.
*Items available in Japan warehouse will be dispatched in 10-12 working days.
*INR price is exclusive of domestic taxes applicable.
*TCI frequently reviews storage conditions to optimize them. Please note that the latest information on the storage temperature for the products is described on our website.

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General Information plus

Specifications & Properties plus

Specifications

Appearance	White to Light yellow powder to crystal
Purity(HPLC)	min. 98.0 area%
Purity(Neutralization titration)	min. 98.0 %
Melting point	142.0 to 146.0 °C
NMR	confirm to structure

Properties (reference)

Melting Point

144 °C

Safety & Regulations plus

GHS

Pictogram
Signal Word	Warning
Hazard Statements	H315 : Causes skin irritation. H319 : Causes serious eye irritation.
Precautionary Statements	P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ eye protection/ face protection. P302 + P352 : IF ON SKIN: Wash with plenty of water. P337 + P313 : If eye irritation persists: Get medical advice/ attention. P305 + P351 + P338 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P362 + P364 : Take off contaminated clothing and wash it before reuse. P332 + P313 : If skin irritation occurs: Get medical advice/ attention.

Related Laws:

RTECS#

UU7785200

Transport Information:

Applications & Literature plus

Application

Ciclopirox: An Antifungal Agent with Additional Antibacterial, Anti-Inflammatory and Antitumor Activities

Ciclopirox is a synthetic, broad-spectrum antifungal agent with additional antibacterial, anti-inflammatory and also recently antitumor activities. In vitro studies have suggested that ciclopirox acts by chelation of trivalent cations, such as Fe³⁺ and Al³⁺, resulting in the inhibition of the metal-dependent enzymes that are responsible for the cellular metabolism, organization of cell wall structure and other crucial cell functions.^1,2) In addition, ciclopirox exerts its anti-inflammatory activity by scavenging the reactive oxygen species (ROS) released from inflammatory cells.²⁾ In 2000s, some studies have reported that ciclopirox olamine [C3545] could be repositioned as a new antitumor agent.^3-5) (The product is for research purpose only.)

References

1) Ciclopirox: an overview
- A. K. Gupta, Int. J. Dermatol. 2001, 40, 305.
2) Ciclopirox: recent nonclinical and clinical data relevant to its use as a topical antimycotic agent (a review)
- A. Subissi, D. Monti, G. Togni, F. Mailland, Drugs 2010, 70, 2133.
3) Chelation of intracellular iron with the antifungal agent ciclopirox olamine induces cell death in leukemia and myeloma cells
- Y. Eberhard, S. P. McDermott, X. Wang, M. Gronda, A. Venugopal, T. E. Wood, R. Hurren, A. Datti, R. A. Batey, J. Wrana, W. E. Antholine, J. E. Dick, A. D. Schimmer, Blood 2009, 114, 3064.
4) The antitumor activity of the fungicide ciclopirox
- H. Zhou, T. Shen, Y. Luo, L. Liu, W. Chen, B. Xu, X. Han, J. Pang, C. A. Rivera, S. Huang, Int. J. Cancer 2010, 127, 2467.
5) The repositioning of the anti-fungal agent ciclopirox olamine as a novel therapeutic agent for the treatment of haematologic malignancy (a review)
- S. J. Weir, L. Patton, K. Castle, L. Rajewski, J. Kasper, A. D. Schimmer, J. Clin. Pharm. Ther. 2011, 36, 128.

Product Documents (Note: Some products will not have analytical charts available.)

Safety Data Sheet (SDS)

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Specifications

C of A & Other Certificates

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Analytical Charts

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Product Number	C3483
Purity / Analysis Method	>98.0%(T)(HPLC)
Molecular Formula / Molecular Weight	C__1__2H__1__7NO__2 = 207.27
Physical State (20 deg.C)	Solid
Storage Temperature	Refrigerated (0-10°C)
Store Under Inert Gas	Store under inert gas
Condition to Avoid	Air Sensitive,Heat Sensitive
Packaging and Container	1G-Glass Bottle with Plastic Insert (View image)
CAS RN	29342-05-0
Reaxys Registry Number	1533423
MDL Number	MFCD00599441

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CAS RN: 29342-05-0 | Product Number: C3483