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CAS RN: 6001-74-7 | Product Number: C3020
Chlormethiazole Hydrochloride
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Purity: >98.0%(T)(HPLC)
Synonyms:
- 5-(2-Chloroethyl)-4-methylthiazole Hydrochloride
- Clomethiazole Hydrochloride
- Somnevrin Hydrochloride
Product Documents:
| Size | Unit Price | Hyderabad | Japan* | Quantity |
|---|---|---|---|---|
| 200MG |
₹9,100.00
|
2 | 12 |
|
| 1G |
₹13,100.00
|
1 | 5 |
|
*Upon orders receipt, Hyderabad stocks will be dispatched on the same day.
*Items available in Japan warehouse will be dispatched in 10-12 working days.
*INR price is exclusive of domestic taxes applicable.
*TCI frequently reviews storage conditions to optimize them. Please note that the latest information on the storage temperature for the products is described on our website.
| Product Number | C3020 |
| Purity / Analysis Method | >98.0%(T)(HPLC) |
| Molecular Formula / Molecular Weight | C__6H__8ClNS·HCl = 198.11 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Room Temperature (Recommended in a cool and dark place, <15°C) |
| Store Under Inert Gas | Store under inert gas |
| Condition to Avoid | Hygroscopic |
| Packaging and Container | 1G-Glass Bottle with Plastic Insert (View image) |
| CAS RN | 6001-74-7 |
| Related CAS RN | 533-45-9 |
| Reaxys Registry Number | 3697289 |
| PubChem Substance ID | 253662385 |
| Merck Index (14) | 2384 |
| MDL Number | MFCD00673948 |
Specifications
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Nonaqueous Titration) | min. 98.0 % |
| Melting point | 134.0 to 138.0 °C |
Properties (reference)
| Melting Point | 136 °C |
| Solubility in water | Soluble |
| Solubility (soluble in) | Alcohol |
GHS
| Pictogram |
|
| Signal Word | Warning |
| Hazard Statements | H315 : Causes skin irritation. H319 : Causes serious eye irritation. |
| Precautionary Statements | P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ eye protection/ face protection. P302 + P352 : IF ON SKIN: Wash with plenty of water. P337 + P313 : If eye irritation persists: Get medical advice/ attention. P305 + P351 + P338 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P362 + P364 : Take off contaminated clothing and wash it before reuse. P332 + P313 : If skin irritation occurs: Get medical advice/ attention. |
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Application
Chlormethiazole Hydrochloride: A Neuroprotective and a CYP2E1 Inhibitory Agent
Chlormethiazole hydrochloride is a thiazole derivative with sedative and anticonvulsive properties. The mechanism of action is considered to involve the potentiation of GABA [A0282] activity, the major intrinsic inhibitory neurotransmitter. Chlormethiazole is also reported to inhibit cytochrome P 450 2E (CYP2E1) which is suggested to alcoholic liver disease. (The product is for research purpose only.)
References
- Neuroprotective activity of chlormethiazole following transient forebrain ischemia in the gerbil
- The pharmacology of chlormethiazole: a potential neuroprotective agent? (A review)
- Chlormethiazole as an efficient inhibitor of cytochrome P450 2E1 expression in rat liver
- nhibition of ethanol-induced liver disease in the intragastric feeding rat model by chlormethiazole
PubMed Literature
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