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CAS RN: 77-36-1 | Product Number: C2898
Chlortalidone
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Purity: >98.0%(T)(HPLC)
Synonyms:
- 2-Chloro-5-(1-hydroxy-3-oxoisoindolin-1-yl)benzenesulfonamide
- 2-Chloro-5-(1-hydroxy-3-oxo-2,3-dihydro-1H-isoindol-1-yl)benzenesulfonamide
Product Documents:
| Size | Unit Price | Hyderabad | Japan* | Quantity |
|---|---|---|---|---|
| 5G |
₹11,500.00
|
Contact Us | 30 |
|
*Upon orders receipt, Hyderabad stocks will be dispatched on the same day.
*Items available in Japan warehouse will be dispatched in 10-12 working days.
*INR price is exclusive of domestic taxes applicable.
*TCI frequently reviews storage conditions to optimize them. Please note that the latest information on the storage temperature for the products is described on our website.
| Product Number | C2898 |
| Purity / Analysis Method | >98.0%(T)(HPLC) |
| Molecular Formula / Molecular Weight | C__1__4H__1__1ClN__2O__4S = 338.76 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Refrigerated (0-10°C) |
| Store Under Inert Gas | Store under inert gas |
| Condition to Avoid | Air Sensitive,Heat Sensitive |
| CAS RN | 77-36-1 |
| Reaxys Registry Number | 312295 |
| MDL Number | MFCD00036257 |
Specifications
| Appearance | White to Light yellow powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Volumetric Analysis) | min. 98.0 % |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 233 °C |
GHS
| Pictogram |
|
| Signal Word | Warning |
| Hazard Statements | H315 : Causes skin irritation. H319 : Causes serious eye irritation. |
| Precautionary Statements | P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ eye protection/ face protection. P302 + P352 : IF ON SKIN: Wash with plenty of water. P337 + P313 : If eye irritation persists: Get medical advice/ attention. P305 + P351 + P338 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P362 + P364 : Take off contaminated clothing and wash it before reuse. P332 + P313 : If skin irritation occurs: Get medical advice/ attention. |
Related Laws:
| RTECS# | DB1556000 |
Transport Information:
Application
Chlorthalidone: A Thiazide Diuretic with Antihypertensive Activity
Chlorthalidone is a thiazide diuretic with antihypertensive activity. Chlorthalidone inhibits sodium reabsorption at the level of the distal convoluted tubule and thus chloride reabsorption via inhibition of the Na/Cl symporter. Although the mechanism of action of chlorthalidone is not fully understood, sodium and water depletion appears to provide a basis for its antihypertensive effect. (The product is for research purpose only.)
References
- Comparative efficacy and safety of chlorthalidone and hydrochlorothiazide—meta-analysis (a review)
- Chlorthalidone (a review)
- Chlorthalidone (a review with of the chemical and physical properties, synthesis, stability, determination in biological fluids, and bioavailability and pharmacokinetics)
- Simple and rapid HPLC method for simultaneous determination of atenolol and chlorthalidone in spiked human plasma
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