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CAS RN: 1075198-30-9 | Product Number: C2733
(1-Cyano-2-ethoxy-2-oxoethylidenaminooxy)dimethylaminomorpholinocarbenium Hexafluorophosphate
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Purity: >95.0%(qNMR)
Synonyms:
Product Documents:
| Size | Unit Price | Hyderabad | Japan* | Quantity |
|---|---|---|---|---|
| 5G |
₹7,800.00
|
2 | 9 |
|
| 25G |
₹23,100.00
|
Contact Us | 23 |
|
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Supplemental Product Information:
This product is unavailable in the U.S.
| Product Number | C2733 |
| Purity / Analysis Method | >95.0%(qNMR) |
| Molecular Formula / Molecular Weight | C__1__2H__1__9F__6N__4O__4P = 428.27 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Refrigerated (0-10°C) |
| Store Under Inert Gas | Store under inert gas |
| Condition to Avoid | Air Sensitive,Moisture Sensitive,Heat Sensitive |
| CAS RN | 1075198-30-9 |
| Reaxys Registry Number | 19762713 |
| MDL Number | MFCD11975052 |
Specifications
| Appearance | White to Almost white powder to crystaline |
| Purity(qNMR) | min. 95.0 % |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 158 °C(dec.) |
GHS
| Pictogram |
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| Signal Word | Warning |
| Hazard Statements | H315 : Causes skin irritation. H319 : Causes serious eye irritation. |
| Precautionary Statements | P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ eye protection/ face protection. P302 + P352 : IF ON SKIN: Wash with plenty of water. P337 + P313 : If eye irritation persists: Get medical advice/ attention. P305 + P351 + P338 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P362 + P364 : Take off contaminated clothing and wash it before reuse. P332 + P313 : If skin irritation occurs: Get medical advice/ attention. |
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Transport Information:
Application
TCI Practical Example: Condensation using (1-Cyano-2-ethoxy-2-oxoethylidenaminooxy)dimethylaminomorpholinocarbenium Hexafluorophosphate
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Used Chemicals
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Procedure
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To a solution of H-Phe-OMe·HCl (0.98 g, 4.6 mmol) in acetonitrile (40 mL) N,N-diisopropylethylamine (1.2 g, 9.2 mmol), Boc-Pro-OH (0.99 g, 4.6 mmol) and (1-cyano-2-ethoxy-2-oxoethylidenaminooxy)dimethylaminomorpholinocarbenium hexafluorophosphate (2.0 g, 4.6 mmol) were successively added at 5 °C then the mixture was stirred overnight at room temperature. The reaction solvent was removed under reduced pressure and the residue was dissolved to ethyl acetate. The organic layer was successively washed with 10% aqueous citric acid solution, 5% aqueous sodium bicarbonate solution and brine, dried over sodium sulfate and filtered. The solvent was removed under reduced pressure and the residue was purified by column chromatography (1:1 ethyl acetate / hexane on SiO2), giving Boc-Pro-Phe-OMe as pale yellow solid (1.4 g, 80% yield).
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Experimenter’s Comments
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The reaction mixture was monitored by TLC (hexane / ethyl acetate = 1 : 1, Rf = 0.40).
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Analytical Data（Boc-Pro-Phe-OMe）
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1H NMR (400 MHz, CDCl3); δ 8.09–8.29 (m, 1H), 7.12–7.35 (m, 5H), 4.39–4.60 (m, 1H), 3.96–4.18 (m, 1H), 3.48–3.70 (m, 3H), 3.14–3.44 (m, 2H), 2.86–3.14 (m, 2H), 1.91–2.11 (m, 1H), 1.50–1.78 (m, 3H), 1.10-1.49 (m, 9H).
13C NMR (101 MHz, CDCl3); δ 172.6, 172.2, 153.3, 137.3, 129.0 (2 C), 128.1 (2 C), 126.5, 78.3, 59.5, 53.4, 51.7, 46.4, 36.4, 30.7, 27.8 (3 C), 22.8.
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Lead Reference
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- Efficient α‐Helix Induction in a Linear Peptide Chain by N‐Capping with a Bridged‐tricyclic Diproline Analogue
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Other References
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- COMU: A Safer and More Effective Replacement for Benzotriazole‐Based Uronium Coupling Reagents
Application
COMU: A Condensing Agent
References
- COMU: A Safer and More Effective Replacement for Benzotriazole-Based Uronium Coupling Reagents
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