Candesartan cilexetili, a prodrug, is hydrolyzed to candesartan during absorption from the gastrointestinal tract. The active metabolite, candesartan, acts as a selective AT
1 subtype angiotensin II receptor antagonist.
Angiotensin II is formed from angiotensin I in a reaction catalyzed by angiotensin-converting enzyme (ACE). Angiotensin II can activate two different receptors, AT
1 and AT
2, both of which are coupled to G-protein. Angiotensin II is the principal pressor agent of the renin-angiotensin system, and the actions of it are mediate through AT
1 receptors. Candesartan has much greater affinity for the AT
1 receptor than for the AT
2 receptor, and blocks of the AT
1 receptor in many tissues by an antagonist suppressed the action of angiotensin II. Candesartan exerts a long-lasting antihypertensive action in spontaneously hypertensive rats. For your reference, [
M2797] is a synthetic intermediate of candesartan cilexetili. (The product is for research purpose only.)