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CAS RN: 132203-70-4 | Product Number: C2564
Cilnidipine
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Purity: >98.0%(HPLC)
Synonyms:
- 1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic Acid 2-Methoxyethyl (2E)-3-Phenyl-2-propenyl Ester
- 2-Methoxyethyl (2E)-3-Phenyl-2-propenyl 1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylate
Product Documents:
| Size | Unit Price | Hyderabad | Japan* | Quantity |
|---|---|---|---|---|
| 1G |
₹6,030.00
|
2 | 11 |
|
| 5G |
₹8,820.00
|
1 | 4 |
|
*Upon orders receipt, Hyderabad stocks will be dispatched on the same day.
*Items available in Japan warehouse will be dispatched in 10-12 working days.
*INR price is exclusive of domestic taxes applicable.
*TCI frequently reviews storage conditions to optimize them. Please note that the latest information on the storage temperature for the products is described on our website.
| Product Number | C2564 |
| Purity / Analysis Method | >98.0%(HPLC) |
| Molecular Formula / Molecular Weight | C__2__7H__2__8N__2O__7 = 492.53 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Room Temperature (Recommended in a cool and dark place, <15°C) |
| Condition to Avoid | Light Sensitive |
| CAS RN | 132203-70-4 |
| Reaxys Registry Number | 9093961 |
| PubChem Substance ID | 135727151 |
| Merck Index (14) | 2275 |
| MDL Number | MFCD00865853 |
Specifications
| Appearance | Light orange to Yellow to Green powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Elemental analysis(Nitrogen) | 5.55 to 5.75 % |
| Melting point | 108.0 to 112.0 °C |
Properties (reference)
| Melting Point | 110 °C |
GHS
Related Laws:
| RTECS# | US7975550 |
Transport Information:
Application
Cilnidipine: A Long-Acting Dual Antagonist of L-Type and N-Type Ca2+ Channels
Cilnidipine (FRC-8653), a dihydropyridine derivative, is a long-acting dual antagonist of L-type Ca2+ channels in vascular smooth muscle and N-type Ca2+ channels in sympathetic nerve terminals that supply blood vessels. Cilnidipine dilates blood vessels by L-type Ca2+ channel antagonism in the vascular smooth muscles, and consequently lower blood pressure. Cilnidipine also inhibits elevation of heart rate and blood pressure under stress by N-type Ca2+ channel antagonism in the sympathetic nerve. (The product is for research purpose only.)
References
- In vitro and ex vivo Ca-antagonistic effect of 2-methoxyethyl (E)-3-phenyl-2-propen-1-yl(±)-1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl) pyridine-3, 5-dicarboxylate (FRC-8653), a new dihydropyridine derivative
- Dual action of FRC8653, a novel dihydropyridine derivative, on the Ba2+ current recorded from the rabbit basilar artery
- Effect of cilnidipine, a novel dihydropyridine Ca2+-channel antagonist, on N-type Ca2+ channel in rat dorsal root ganglion neurons
- Selectivity of dihydropyridines for cardiac L-type and sympathetic N-type Ca2+ channels
- Cilnidipine: a new generation Ca2+ channel blocker with inhibitory action on sympathetic neurotransmitter release (a review).
- Analytical methodologies for determination of cilnidipine: an overview
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