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CAS RN: 848695-25-0 | Product Number: B5775
BIIB 021
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Purity: >98.0%(HPLC)
Synonyms:
- 6-Chloro-9-[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]-9H-purin-2-amine
Product Documents:
| Size | Unit Price | Hyderabad | Japan* | Quantity |
|---|---|---|---|---|
| 25MG |
₹5,040.00
|
1 | 6 |
|
| 100MG |
₹11,520.00
|
Contact Us | 11 |
|
*Upon orders receipt, Hyderabad stocks will be dispatched on the same day.
*Items available in Japan warehouse will be dispatched in 10-12 working days.
*INR price is exclusive of domestic taxes applicable.
*TCI frequently reviews storage conditions to optimize them. Please note that the latest information on the storage temperature for the products is described on our website.
| Product Number | B5775 |
| Purity / Analysis Method | >98.0%(HPLC) |
| Molecular Formula / Molecular Weight | C__1__4H__1__5ClN__6O = 318.77 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Frozen (<0°C) |
| Store Under Inert Gas | Store under inert gas |
| Condition to Avoid | Air Sensitive,Heat Sensitive |
| CAS RN | 848695-25-0 |
| Reaxys Registry Number | 11080986 |
| MDL Number | MFCD15528939 |
Specifications
| Appearance | White to Light yellow to Light orange powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Elemental analysis(Nitrogen) | 25.00 to 27.50 % |
| Melting point | 186.0 to 190.0 °C |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 189 °C |
GHS
| Pictogram |
|
| Signal Word | Warning |
| Hazard Statements | H315 : Causes skin irritation. H319 : Causes serious eye irritation. |
| Precautionary Statements | P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ eye protection/ face protection. P302 + P352 : IF ON SKIN: Wash with plenty of water. P337 + P313 : If eye irritation persists: Get medical advice/ attention. P305 + P351 + P338 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P362 + P364 : Take off contaminated clothing and wash it before reuse. P332 + P313 : If skin irritation occurs: Get medical advice/ attention. |
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Application
BIIB021: A Heat Shock Protein 90 (HSP90) Inhibitor with Antitumor Activity
BIIB021 (also called CNF2024) is the first oral, synthetic heat shock protein 90 (HSP90) inhibitor. Reportedly, BIIB021 induces the apoptosis of various types of tumor cell in vitro and in vivo.1-4) HSP90 is a chaperone protein that assists other proteins to fold properly, stabilizes proteins against heat stress, and aids in protein degradation. It has recently been reported that HSP90 also stabilizes a number of proteins required for tumor growth. Therefore, HSP90 inhibitors have been investigated as anticancer agents.5)
References
- BIIB021, an orally available, fully synthetic small-molecule inhibitor of the heat shock protein Hsp90
- BIIB021, a synthetic Hsp90 inhibitor, has broad application against tumors with acquired multidrug resistance
- BIIB021, a novel Hsp90 inhibitor, sensitizes head and neck squamous cell carcinoma to radiotherapy
- The discovery of BIIB021 and BIIB028 (a review)
- Heat shock proteins: a potential anticancer target (a review)
Articles/Brochures
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