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CAS RN: 91599-74-5 | Product Number: B5629
Benidipine Hydrochloride
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Purity: >98.0%(T)(HPLC)
Synonyms:
- 3-[(3RS)-1-Benzylpiperidin-3-yl] 5-Methyl (4RS)-2,6-Dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate Hydrochloride
- KW‐3049
Product Documents:
| Size | Unit Price | Hyderabad | Japan* | Quantity |
|---|---|---|---|---|
| 100MG |
₹5,900.00
|
Contact Us | 8 |
|
| 1G |
₹17,600.00
|
1 | 11 |
|
*Upon orders receipt, Hyderabad stocks will be dispatched on the same day.
*Items available in Japan warehouse will be dispatched in 10-12 working days.
*INR price is exclusive of domestic taxes applicable.
*TCI frequently reviews storage conditions to optimize them. Please note that the latest information on the storage temperature for the products is described on our website.
| Product Number | B5629 |
| Purity / Analysis Method | >98.0%(T)(HPLC) |
| Molecular Formula / Molecular Weight | C__2__8H__3__1N__3O__6·HCl = 542.03 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Frozen (<0°C) |
| Condition to Avoid | Heat Sensitive |
| CAS RN | 91599-74-5 |
| Related CAS RN | 105979-17-7 |
| Reaxys Registry Number | 6764011 |
| PubChem Substance ID | 468590637 |
| Merck Index (14) | 1043 |
| MDL Number | MFCD00906929 |
Specifications
| Appearance | Light yellow to Yellow to Orange powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Nonaqueous Titration) | min. 98.0 % |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 200 °C |
| Maximum Absorption Wavelength | 359(EtOH) nm |
| Solubility (soluble in) | Methanol |
| Solubility (slightly sol. in) | Ethanol |
| Solubility (insoluble in) | Heptane, Toluene |
GHS
| Pictogram |
|
| Signal Word | Danger |
| Hazard Statements | H301 : Toxic if swallowed. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P270 : Do not eat, drink or smoke when using this product. P264 : Wash skin thoroughly after handling. P301 + P310 + P330 : IF SWALLOWED: Immediately call a POISON CENTER/doctor. Rinse mouth. P405 : Store locked up. |
Related Laws:
| RTECS# | US7975657 |
Transport Information:
| UN Number | UN2811 |
| Class | 6.1 |
| Packing Group | III |
Application
Benidipine Hydrochloride: A Long-Acting Dihydropyridine-Derived Calcium Channel Antagonist
Benidipine hydrochloride (KW-3049) is a long-acting dihydropyridine-derived calcium channel antagonist with several unique mechanisms of action. It is reported that benidipine is highly transferable into the cell membranes, and combines with the dihydropyridine (DHP) binding site of the potential-dependent calcium channel in the cell membranes and thereby inhibits calcium influx into cells and causes coronary and peripheral vessels to dilate. (The product is for research purpose only.)
文献
- Calcium Antagonistic Effects and the In Vitro Duration of Actions of KW-3049, a New 1, 4-Dihydropyridine Derivative, in Isolated Canine Coronary Arteries
- Binding Properties of (±)[3H]Benidipine Hydrochloride to Rat Heart Membranes
- Pharmacological, pharmacokinetic, and clinical properties of Benidipine hydrochloride, a novel, long-acting calcium channel blocker (a review)
- Physico-chemical properties and stabilities of the highly potent calcium antagonist benidipine hydrochloride
- Analysis of enantiomers in human plasma by liquid chromatography-mass spectrometry using a macrocyclic antibiotic (Vancomycin) chiral stationary phase column
- Voltammetric and RP-LC assay for determination of benidipine HCl
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