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CAS RN: 42864-78-8 | Product Number: B5372
Bevantolol Hydrochloride
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Purity: >98.0%(HPLC)
Synonyms:
- 1-[[2-(3,4-Dimethoxyphenyl)ethyl]amino]-3-(3-methylphenoxy)-2-propanol Hydrochloride
- 1-[(3,4-Dimethoxyphenethyl)amino]-3-(m-tolyloxy)propan-2-ol Hydrochloride
Product Documents:
| Size | Unit Price | Hyderabad | Japan* | Quantity |
|---|---|---|---|---|
| 250MG |
₹8,600.00
|
2 | 2 |
|
| 1G |
₹21,200.00
|
7 | 3 |
|
*Upon orders receipt, Hyderabad stocks will be dispatched on the same day.
*Items available in Japan warehouse will be dispatched in 10-12 working days.
*INR price is exclusive of domestic taxes applicable.
*TCI frequently reviews storage conditions to optimize them. Please note that the latest information on the storage temperature for the products is described on our website.
| Product Number | B5372 |
| Purity / Analysis Method | >98.0%(HPLC) |
| Molecular Formula / Molecular Weight | C__2__0H__2__7NO__4·HCl = 381.90 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Room Temperature (Recommended in a cool and dark place, <15°C) |
| Packaging and Container | 1G-Glass Bottle with Plastic Insert (View image), 250MG-Glass Bottle with Plastic Insert (View image) |
| CAS RN | 42864-78-8 |
| Related CAS RN | 59170-23-9 |
| Reaxys Registry Number | 5195067 |
| PubChem Substance ID | 354334983 |
| Merck Index (14) | 1192 |
| MDL Number | MFCD00941389 |
Specifications
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(with Total Nitrogen) | min. 97.0 % |
| Melting point | 139.0 to 144.0 °C |
Properties (reference)
| Melting Point | 142 °C |
| Solubility (soluble in) | Chloroform |
| Solubility (insoluble in) | Ether |
GHS
| Pictogram |
|
| Signal Word | Warning |
| Hazard Statements | H302 : Harmful if swallowed. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P270 : Do not eat, drink or smoke when using this product. P264 : Wash skin thoroughly after handling. P301 + P312 + P330 : IF SWALLOWED: Call a POISON CENTER/doctor if you feel unwell. Rinse mouth. |
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Application
Bevantolol Hydrochloride: A β1-Adrenoceptor Antagonist with an Affinity to α1-Adrenoceptors
Bevantolol hydrochloride (NC-1400) is a β1-adrenoceptor antagonist with a relatively high affinity to α1-adrenoceptor subtypes, and also acts as calcium channel antagonist. Bevantolol has a peripheral vasodilatory effect, and is used for the treatment of angina and hypertension. In addition, bevantolol hydrochloride is a racemic mixture, and methods have been developed for the enantioselective separation. (The product is for research purpose only.)
References
- (±)-1-[[2-(3,4-Dimethoxphenyl)ethyl]amino]-3-(3-methylphenoxy)-2-propanol hydrochloride (bevantolol, NC-1400) as a β1-selective adrenoceptor blocker with α1-adrenoceptor blocking activity
- Alpha1-adrenoceptor blocking activities of bevantolol hydrochloride(NC-1400) and labetalol in rat isolated thoracic aorta - Do they distinguish between subtypes?
- Bevantolol. A preliminary review of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy in hypertension and angina pectoris
- Quantitative analysis of β-adrenergic blocking agents by NMR spectroscopy
- Chiral purity test of bevantolol by capillary electrophoresis and high performance liquid chromatography
- Determination of bevantolol enantiomers in human plasma by coupled achiral-chiral high performance-liquid chromatography
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