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CAS RN: 19916-73-5 | Product Number: B4208
O6-Benzylguanine
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Purity: >98.0%(T)(HPLC)
Synonyms:
- 2-Amino-6-benzyloxypurine
- 6-(Benzyloxy)-9H-purin-2-amine
Product Documents:
| Size | Unit Price | Hyderabad | Japan* | Quantity |
|---|---|---|---|---|
| 5G |
₹3,500.00
|
Contact Us | 35 |
|
| 25G |
₹12,500.00
|
Contact Us | 39 |
|
*Upon orders receipt, Hyderabad stocks will be dispatched on the same day.
*Items available in Japan warehouse will be dispatched in 10-12 working days.
*INR price is exclusive of domestic taxes applicable.
*TCI frequently reviews storage conditions to optimize them. Please note that the latest information on the storage temperature for the products is described on our website.
| Product Number | B4208 |
| Purity / Analysis Method | >98.0%(T)(HPLC) |
| Molecular Formula / Molecular Weight | C__1__2H__1__1N__5O = 241.25 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Room Temperature (Recommended in a cool and dark place, <15°C) |
| Store Under Inert Gas | Store under inert gas |
| Condition to Avoid | Air Sensitive |
| CAS RN | 19916-73-5 |
| Reaxys Registry Number | 753284 |
| MDL Number | MFCD00269931 |
Specifications
| Appearance | White to Light yellow powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Nonaqueous Titration) | min. 98.0 % |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 205 °C |
| Maximum Absorption Wavelength | 284(MeOH) nm |
| Solubility in water | Insoluble |
| Degree of solubility in water | 87.1 mg/l 20 °C |
GHS
| Pictogram |
|
| Signal Word | Warning |
| Hazard Statements | H302 : Harmful if swallowed. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P270 : Do not eat, drink or smoke when using this product. P264 : Wash skin thoroughly after handling. P301 + P312 + P330 : IF SWALLOWED: Call a POISON CENTER/doctor if you feel unwell. Rinse mouth. |
Related Laws:
| RTECS# | UO7444900 |
Transport Information:
Application
O6-Benzylguanine: An Inhibitor of O6-Alkyulguanine DNA Alkyltransferase (AGT)
O6-Alkyulguanine DNA alkyltransferase (AGT, a protein encoded by the gene MGMT) is a unique DNA repair protein that acts as a single agent to directly remove alkyl groups located at the O6 position of guanine from DNA, restoring DNA in one step and is responsible for protecting both tumor and normal cells from DNA-damaging chemotherapeutic agents. O6-Benzylguanine, a guanine analog, is an inhibitor of AGT and depletes AGT in human tumors. And then, inactivation of AGT increases the efficacy of chemotherapeutic agents. (The product is for research purpose only.)
References
- Repair of O6-alkylguanine by alkyltransferases (a review)
- Clinical relevance of MGMT in the treatment of cancer (a review)
- Multifaceted Roles of Alkyltransferase and Related Proteins in DNA Repair, DNA Damage, Resistance to Chemotherapy, and Research Tools (a review)
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